Evidence map›Paper›PMID 34768516›Full record

ArticleJournal of clinical medicine2021

A Prospective, Single Arm, Multi-Center Study Evaluating the Clinical Outcomes of Ventral Hernias Treated with OviTex

George DeNoto, Eugene P Ceppa, Salvatore J Pacella, Michael Sawyer, Geoffrey Slayden, Mark Takata, Gary Tuma, Jonathan Yunis

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  6. Review
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  8. Outcomes of Biosynthetic and Synthetic Mesh in Ventral Hernia Repair.Plastic and reconstructive surgery. Global open · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

George DeNotoDepartment of General Surgery, St. Francis Hospital, Roslyn, NY 11576, USA.
Eugene P CeppaDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Salvatore J PacellaScripps Clinic and Scripps M.D. Anderson Cancer Center, Division of Plastic and Reconstructive Surgery, San Diego, CA 92130, USA.
Michael SawyerDepartment of Surgery, Comanche County Memorial Hospital, Lawton, OK 73505, USA.ORCID 0000-0001-7269-3836
Geoffrey SlaydenSt. Luke's Surgical Specialists, St. Luke's Health System, Overland Park, KS 66213, USA.
Mark TakataScripps Clinic Medical Group, Department of Surgery, La Jolla, CA 92037, USA.
Gary TumaCapital Health Medical Group, Department of Plastic Surgery, Pennington, NJ 08534, USA.
Jonathan YunisHernia Specialist, Center for Hernia Repair, Sarasota, FL 34239, USA.
Capital Health · USComanche County Juvenile Bureau · USHernia Center · USIndiana University School of MedicineSaint Luke's Health System · USScripps Clinic · USScripps Clinic Medical Group · USSt. Francis Hospital · US

Funding

TELA Bio Inc N/A
6 · The paper itself

Abstract

backgroundConflicting results from previous studies have led to dissent over whether surgical mesh is safe and effective in ventral hernia repair. A newer class of mesh known as a reinforced tissue matrix, combining a biologic scaffold and minimal polymer reinforcement, offers promise in reducing inflammatory response and increasing abdominal wall support. This study sought to assess the clinical utility of a reinforced tissue matrix (OviTex) in ventral hernia repair 12 months after implantation.

methodsThis is a prospective, single-arm, multi-center study to evaluate the clinical performance of OviTex

resultsNinety-two (92) patients were enrolled in the study, of whom seventy-six (76) reached the 12-month follow-up. All patients were at least 18 years of age with a BMI of <40 kg/m

conclusionsThe low rate of hernia recurrence and SSOs requiring intervention illustrates the potential that reinforced tissue matrices, and OviTex 1S, in particular, have to improve outcomes in VH repairs. Follow-up to 24 months is ongoing.

Indexed as

decellularized extracellular matrixrecurrencereinforced tissue matrixventral hernia repair

Identifiers

PMID34768516
PMCPMC8584945
OpenAlexW3210822875

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.