Evidence map›Paper›PMID 34768474›Full record

ArticleJournal of clinical medicine2021

Out-of-Hospital Treatment of Hepatitis C Increases Retention in Care among People Who Inject Drugs and Homeless Persons: An Observational Study.

Bianca Granozzi, Viola Guardigni, Lorenzo Badia, Elena Rosselli Del Turco, Alberto Zuppiroli, Beatrice Tazza, Pietro Malosso, Stefano Pieralli, Pierluigi Viale, Gabriella Verucchi

Abstract read
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Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bianca GranozziInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Viola GuardigniInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Lorenzo BadiaInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Elena Rosselli Del TurcoInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Alberto ZuppiroliInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Beatrice TazzaInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Pietro MalossoInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Stefano PieralliOpen Group Society Coop. Soc. Onlus, 40139 Bologna, Italy.
Pierluigi VialeInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.
Gabriella VerucchiInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy.ORCID 0000-0001-6546-0495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople who inject drugs (PWID) and homeless people represent now a large reservoir of Hepatitis C virus (HCV) infection. However, Hepatis C elimination programs can barely reach these subgroups of patients. We aimed to evaluate and compare the retention in care among these difficult-to-treat patients when managed for HCV in hospital or in an out-of-hospital setting.

methodsIn our retrospective study, we categorized the included patients (PWID and homeless persons) into two groups according to whether anti-HCV treatment was offered and provided in a hospital or an out-of-hospital setting. We run logistic regressions to evaluate factors associated with retention in care (defined as the completion of direct antiviral agents (DAAs) therapy).

resultsWe included 56 patients in our study: 27 were in the out-of-hospital group. Overall, 33 patients completed DAAs therapy. A higher rate of retention in care was observed in the out-of-hospital group rather than in-hospital group (

conclusionsThe choice of treatment models that can better adapt to difficult-to-treat populations, such as an out-of-hospital approach, will be important for achieving the eradication of HCV infection.

Indexed as

direct-acting antiviralsHCV eradicationhomeless personsout-of-hospitalPWIDretention in care

Identifiers

PMID34768474
PMCPMC8584608

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