Evidence map›Paper›PMID 34768468›Full record

ReviewJournal of clinical medicine2021

The Role of Magnetic Resonance Imaging to Inform Clinical Decision-Making in Acute Spinal Cord Injury: A Systematic Review and Meta-Analysis.

Arash Ghaffari-Rafi, Catherine Peterson, Jose E Leon-Rojas, Nobuaki Tadokoro, Stefan F Lange, Mayank Kaushal, Lindsay Tetreault, Michael G Fehlings, Allan R Martin

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Imaging strategies for patients with multiple and/or severe injuries in the resuscitation room: a systematic review and clinical practice guideline update.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Blast Injuries.Advances and technical standards in neurosurgery · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Prognostic MRI parameters in acute traumatic cervical spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Arash Ghaffari-RafiDepartment of Neurological Surgery, University of California, Davis, CA 95817, USA.
Catherine PetersonDepartment of Neurological Surgery, University of California, Davis, CA 95817, USA.
Jose E Leon-RojasNeurALL Research Group, Escuela de Medicina, Universidad Internacional del Ecuador, Quito 170411, Ecuador.ORCID 0000-0002-8130-6460
Nobuaki TadokoroDepartment of Orthopaedic Surgery, Kochi University, Nankoku 783-0000, Japan.
Stefan F LangeDepartment of Neurosurgery, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.
Mayank KaushalDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Lindsay TetreaultDepartment of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, Canada.
Michael G FehlingsDepartment of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, Canada.ORCID 0000-0002-5722-6364
Allan R MartinDepartment of Neurological Surgery, University of California, Davis, CA 95817, USA.
University of Toronto · CAKōchi University · JPMedical College of Wisconsin · USNeurological Surgery · USUniversidad Internacional del Ecuador · ECUniversity Medical Center Groningen · NLUniversity of Hawaiʻi at Mānoa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical indications and added value of obtaining MRI in the acute phase of spinal cord injury (SCI) remain controversial. This review aims to critically evaluate evidence regarding the role of MRI to influence decision-making and outcomes in acute SCI. A systematic review and meta-analysis were performed according to PRISMA methodology to identify studies that address six key questions (KQs) regarding diagnostic accuracy, frequency of abnormal findings, frequency of altered decision-making, optimal timing, and differences in outcomes related to obtaining an MRI in acute SCI. A total of 32 studies were identified that addressed one or more KQs. MRI showed no adverse events in 156 patients (five studies) and frequently identified cord compression (70%, 12 studies), disc herniation (43%, 16 studies), ligamentous injury (39%, 13 studies), and epidural hematoma (10%, two studies), with good diagnostic accuracy (seven comparative studies) except for fracture detection. MRI findings often altered management, including timing of surgery (78%, three studies), decision to operate (36%, 15 studies), and surgical approach (29%, nine studies). MRI may also be useful to determine the need for instrumentation (100%, one study), which levels to decompress (100%, one study), and if reoperation is needed (34%, two studies). The available literature consistently concluded that MRI was useful prior to surgical treatment (13 studies) and after surgery to assess decompression (two studies), but utility before/after closed reduction of cervical dislocations was unclear (three studies). One study showed improved outcomes with an MRI-based protocol but had a high risk of bias. Heterogeneity was high for most findings (I

Indexed as

magnetic resonance imagingMRISCIspinal cord injuryspine trauma

Identifiers

PMID34768468
PMCPMC8584859
OpenAlexW3210822796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.