Evidence map›Paper›PMID 34768452›Full record

ArticleJournal of clinical medicine2021

Sarcopenia, Obesity, and Sarcopenic Obesity: Relationship with Skeletal Muscle Phenotypes and Single Nucleotide Polymorphisms.

Praval Khanal, Alun G Williams, Lingxiao He, Georgina K Stebbings, Gladys L Onambele-Pearson, Martine Thomis, Hans Degens, Christopher I Morse

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Metabolic Health and Fitness Do Not Differ Substantially Between Overweight Adults With and Without α-Actinin-3 Deficiency.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  7. Sarcopenia and MASLD: novel insights and the future.Nature reviews. Endocrinology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Praval KhanalMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0003-2060-8446
Alun G WilliamsMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-8052-8184
Lingxiao HeMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-2395-6035
Georgina K StebbingsMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0003-0706-2864
Gladys L Onambele-PearsonMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-1466-3265
Martine ThomisPhysical Activity, Sports & Health Research Group, Department of Movement Sciences, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0001-9093-2191
Hans DegensMusculoskeletal Science and Sports Medicine Research Centre, Department of Life Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0001-7399-4841
Christopher I MorseMusculoskeletal Science and Sports Medicine Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester M15 6BH, UK.ORCID 0000-0002-5261-2637
Manchester Metropolitan University · GBKU Leuven · BE

Funding

MOVE-AGE Erasmus Mundus Joint Doctorate programme (2011-0015)
6 · The paper itself

Abstract

Obesity may aggravate the effects of sarcopenia on skeletal muscle structure and function in the elderly, but no study has attempted to identify the gene variants associated with sarcopenia in obese women. Therefore, the aims of the present study were to: (1) describe neuromuscular function in sarcopenic and non-sarcopenic women with or without obesity; (2) identify gene variants associated with sarcopenia in older obese women. In 307 Caucasian women (71 ± 6 years, 66.3 ± 11.3 kg), skeletal muscle mass was estimated using bioelectric impedance, and function was tested with a 30 s one-leg standing-balance test. Biceps brachii thickness and vastus lateralis cross-sectional area (VL

Indexed as

elderlyneuromuscularsarcopenic obesesingle-nucleotide polymorphisms

Identifiers

PMID34768452
PMCPMC8584842
OpenAlexW3208078132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.