ArticleJournal of clinical medicine2021
A Novel Multi-Dimensional Clinical Response Index Dedicated to Improving Global Assessment of Pain in Patients with Persistent Spinal Pain Syndrome after Spinal Surgery, Based on a Real-Life Prospective Multicentric Study (PREDIBACK) and Machine Learning Techniques.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02964130 (A Multicenter Prospective Study on Failed Back Surgery Syndrome Pathway Optimization), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Prospective Study on Failed Back Surgery Syndrome Pathway Optimization: A Focus on Patient Identification, Chronicization Factors and Outcome Predictors
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Comparison of Spinal Cord Stimulation vs. Dorsal Root Ganglion Stimulation vs. Association of Both in Patients with Refractory Chronic Back and/or Lower Limb Neuropathic Pain: An International, Prospective, Randomized, Double-Blinded, Crossover Trial (BOOST-DRG Study).Medicina (Kaunas, Lithuania) · 2021Trial
- Location-Specific Disruption of the Body Schema in Chronic Low Back Pain.Archives of rehabilitation research and clinical translation · 2026Article
- Pain Relief and Multidimensional Outcomes of Fast-Acting Subperception Spinal Cord Stimulation Therapy for Chronic Pain: The FAST Prospective, Multicenter Study.Pain and therapy · 2026Article
- A Systematic Review of Pain Drawings for Perioperative Patient Management.Plastic and reconstructive surgery. Global open · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Associations between pain experiences and gray matter volume in youth in the adolescent brain cognitive development (ABCD) study.The journal of pain · 2025Article
- Summary and Analysis of Digital Pain Manikin Data in Adults With Pain Experience: Scoping Review.Journal of medical Internet research · 2025Article
- The Added Value of Digital Body Chart Pain Surface Assessment as an Objective Biomarker: Multicohort Study.Journal of medical Internet research · 2025Observational
- Scoping Review of Machine Learning and Patient-Reported Outcomes in Spine Surgery.Bioengineering (Basel, Switzerland) · 2025Review
- Effects of combining cold exposure and compression on muscle recovery: a randomized crossover study.Frontiers in physiology · 2025Article
- A digital tool for multidimensional assessment and prediction of treatment effectiveness in chronic pain management.iScience · 2024Article
- Improved Outcomes and Therapy Longevity after Salvage Using a Novel Spinal Cord Stimulation System for Chronic Pain: Multicenter, Observational, European Case Series.Journal of clinical medicine · 2024Article
- "Neuro-Fiber Mapping": An Original Concept of Spinal Cord Neural Network Spatial Targeting Using Live Electrostimulation Mapping to (Re-)Explore the Conus Medullaris Anatomy.Journal of clinical medicine · 2023Article
- Article
- Research hotspots and trends on spinal cord stimulation for pain treatment: a two-decade bibliometric analysis.Frontiers in neuroscience · 2023Article
- Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement.Journal of clinical medicine · 2022Article
- Goals, Expectations, and the Definition of Success for Neuromodulation for Pain According to Representatives of Neuromodulation Device Manufacturers.Journal of personalized medicine · 2022Article
- A 6-Month Home-Based Functional Electrical Stimulation Program for Foot Drop in a Post-Stroke Patient: Considerations on a Time Course Analysis of Walking Performance.International journal of environmental research and public health · 2022Article
- The Challenge of Converting "Failed Spinal Cord Stimulation Syndrome" Back to Clinical Success, Using SCS Reprogramming as Salvage Therapy, through Neurostimulation Adapters Combined with 3D-Computerized Pain Mapping Assessment: A Real Life Retrospective Study.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 2 countries.
Funding
Abstract
The multidimensionality of chronic pain forces us to look beyond isolated assessment such as pain intensity, which does not consider multiple key parameters, particularly in post-operative Persistent Spinal Pain Syndrome (PSPS-T2) patients. Our ambition was to produce a novel Multi-dimensional Clinical Response Index (MCRI), including not only pain intensity but also functional capacity, anxiety-depression, quality of life and quantitative pain mapping, the objective being to achieve instantaneous assessment using machine learning techniques. Two hundred PSPS-T2 patients were enrolled in the real-life observational prospective PREDIBACK study with 12-month follow-up and received various treatments. From a multitude of questionnaires/scores, specific items were combined, as exploratory factor analyses helped to create a single composite MCRI; using pairwise correlations between measurements, it appeared to more accurately represent all pain dimensions than any previous classical score. It represented the best compromise among all existing indexes, showing the highest sensitivity/specificity related to Patient Global Impression of Change (PGIC). Novel composite indexes could help to refine pain assessment by informing the physician's perception of patient condition on the basis of objective and holistic metrics, and also by providing new insights regarding therapy efficacy/patient outcome assessments, before ultimately being adapted to other pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.