Evidence map›Paper›PMID 34768424›Full record

ArticleJournal of clinical medicine2021

The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer.

Arkadiusz Zygmunt, Kinga Krawczyk-Rusiecka, Elżbieta Skowrońska-Jóźwiak, Katarzyna Wojciechowska-Durczyńska, Ewa Głowacka, Zbigniew Adamczewski, Andrzej Lewiński

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arkadiusz ZygmuntDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.
Kinga Krawczyk-RusieckaDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.
Elżbieta Skowrońska-JóźwiakDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.ORCID 0000-0002-0019-4269
Katarzyna Wojciechowska-DurczyńskaDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.
Ewa GłowackaDepartment of Laboratory Diagnostics, Research Institute, Polish Mother's Memorial Hospital, 93-338 Lodz, Poland.
Zbigniew AdamczewskiDepartment of Endocrinology and Metabolic Diseases, Research Institute, Polish Mother's Memorial Hospital, 93-338 Lodz, Poland.ORCID 0000-0001-8713-6936
Andrzej LewińskiDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.ORCID 0000-0002-8748-3337
Medical University of Lodz · PLPolish Mother’s Memorial Hospital Research Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total thyroidectomy for differentiated thyroid cancer (DTC), without any signs of disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, the patients were administered a standard dose of 0.9 mg rhTSH, i.m. Concentrations of sclerostin, osteocalcin, β-CrossLaps, PTH, and some other parameters, were measured before and five days after the first rhTSH administration. The greater the increase in TSH concentration (∆TSH), the greater the decrease in: ∆sclerostin (r = -0.672;

Indexed as

bone turnover markersparathormonsclerostinthyrotropin

Identifiers

PMID34768424
PMCPMC8584503
OpenAlexW3209425594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.