Evidence map›Paper›PMID 34768335›Full record

ArticleJournal of clinical medicine2021

Genetic Variation in

Thies Bartram, Peter Schütte, Anja Möricke, Richard S Houlston, Eva Ellinghaus, Martin Zimmermann, Anke Bergmann, Britt-Sabina Löscher, Norman Klein, Laura Hinze and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Thies BartramDepartment of Pediatrics, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Peter SchütteDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Anja MörickeDepartment of Pediatrics, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Richard S HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK.
Eva EllinghausInstitute of Clinical Molecular Biology, Kiel University, 24118 Kiel, Germany.ORCID 0000-0003-2914-3382
Martin ZimmermannDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Anke BergmannDepartment of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Britt-Sabina LöscherInstitute of Clinical Molecular Biology, Kiel University, 24118 Kiel, Germany.
Norman KleinDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Laura HinzeDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Stefanie V JunkDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-8206-9463
Michael ForsterInstitute of Clinical Molecular Biology, Kiel University, 24118 Kiel, Germany.ORCID 0000-0001-9927-5124
Claus R BartramDepartment of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Rolf KöhlerDepartment of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, 24118 Kiel, Germany.
Martin SchrappeDepartment of Pediatrics, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Christian P KratzDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Gunnar CarioDepartment of Pediatrics, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Martin StanullaDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DEChristian-Albrechts-Universität zu Kiel · DEUniversity Hospital Schleswig-Holstein · DEHeidelberg University · DEInstitute of Cancer Research · GB

Funding

Madeleine Schickedanz Kinderkrebsstiftung 19374451
6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is a serious, mechanistically not entirely resolved side effect of L-asparaginase-containing treatment for acute lymphoblastic leukemia (ALL). To find new candidate variations for AP, we conducted a genome-wide association study (GWAS).

methodsIn all, 1,004,623 single-nucleotide variants (SNVs) were analyzed in 51 pediatric ALL patients with AP (cases) and 1388 patients without AP (controls). Replication used independent patients.

resultsThe top-ranked SNV (rs4148513) was located within the

conclusionsGenetic variation within the

Indexed as

ABCC4acute lymphoblastic leukemiaacute pancreatitisCFTRL-asparaginasepolymorphismSNV

Identifiers

PMID34768335
PMCPMC8584334
OpenAlexW3206688925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.