Evidence map›Paper›PMID 34768332›Full record

ArticleJournal of clinical medicine2021

Clinical Practice Guidelines on the Treatment of Patients with Cleft Lip, Alveolus, and Palate: An Executive Summary.

Aebele B Mink van der Molen, Johanna M M van Breugel, Nard G Janssen, Ronald J C Admiraal, Leon N A van Adrichem, Frank Bierenbroodspot, Dirk Bittermann, Marie-José H van den Boogaard, Pieter H Broos, Janet J M Dijkstra-Putkamer and 8 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Comparison of Goslon Yardstick and Cephalometric Analysis in Nonsyndromic Unilateral Cleft lip and Palate Individuals in the Western Cape, South Africa.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  3. Burden of Travel is not Associated with Adherence to Follow-up Appointments - A Call for Centralization of Cleft Care in Germany.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Aebele B Mink van der MolenDepartment of Plastic and Reconstructive Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Johanna M M van BreugelDepartment of Plastic and Reconstructive Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Nard G JanssenDepartment Maxillo Facial Surgery and Dentistry, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Ronald J C AdmiraalDepartment of Oto-Rhino-Laryngology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Leon N A van AdrichemDepartment of Plastic and Reconstructive Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Frank BierenbroodspotDepartment Maxillo Facial Surgery, Isala, 8025 AB Zwolle, The Netherlands.
Dirk BittermannDepartment Maxillo Facial Surgery and Dentistry, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Marie-José H van den BoogaardDepartment of Clinical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Pieter H BroosKnowledge Institute of the Federation of Medical Specialists, 3528 BL Utrecht, The Netherlands.
Janet J M Dijkstra-PutkamerDepartment of Speech Therapy, Medical Center Leeuwarden, 8934 AD Leeuwarden, The Netherlands.
Martine C M van Gemert-SchriksAcademic Dentistry Center (ACTA), 1081 LA Amsterdam, The Netherlands.
Andrea L J KortleverKnowledge Institute of the Federation of Medical Specialists, 3528 BL Utrecht, The Netherlands.
Chantal M Mouës-VinkDepartment of Plastic and Reconstructive Surgery, Medical Center Leeuwarden, 8934 AD Leeuwarden, The Netherlands.
Henriette F N Swanenburg de VeyeDepartment Medical Psychology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Nanouk van Tol-VerbeekAssociation of Educationalists in the Netherlands, 3527 GV Utrecht, The Netherlands.
Christl Vermeij-KeersDutch Association for Cleft Palate and Craniofacial Anomalies, 3643 AE Mijdrecht, The Netherlands.
Hester de WildeDepartment of Speech Therapy, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Anne Marie Kuijpers-JagtmanDepartment of Orthodontics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8172-0090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant treatment variation exists in the Netherlands between teams treating patients with cleft lip, alveolus, and/or palate, resulting in a confusing and undesirable situation for patients, parents, and practitioners. Therefore, to optimize cleft care, clinical practice guidelines (CPGs) were developed. The aim of this report is to describe CPG development, share the main recommendations, and indicate knowledge gaps regarding cleft care. Together with patients and parents, a multidisciplinary working group of representatives from all relevant disciplines assisted by two experienced epidemiologists identified the topics to be addressed in the CPGs. Searching the Medline, Embase, and Cochrane Library databases identified 5157 articles, 60 of which remained after applying inclusion and exclusion criteria. We rated the quality of the evidence from moderate to very low. The working group formulated 71 recommendations regarding genetic testing, feeding, lip and palate closure, hearing, hypernasality, bone grafting, orthodontics, psychosocial guidance, dentistry, osteotomy versus distraction, and rhinoplasty. The final CPGs were obtained after review by all stakeholders and allow cleft teams to base their treatment on current knowledge. With high-quality evidence lacking, the need for additional high-quality studies has become apparent.

Indexed as

cleft lip, alveolus and palateclinical practice guidelinequality of health carerecommendation clinical caretreatment

Identifiers

PMID34768332
PMCPMC8584510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.