Evidence map›Paper›PMID 34768282›Full record

ArticleBlood advances2022

Coping strategies in patients with acute myeloid leukemia.

Hermioni L Amonoo, Monica H Bodd, Matthew J Reynolds, Ashley M Nelson, Richard Newcomb, Patrick Connor Johnson, Tejaswini M Dhawale, Rachel Plotke, Lauren Heuer, Sabah Gillani and 8 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  9. In their own words: a qualitative study of coping mechanisms employed by patients with acute myeloid leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Hermioni L AmonooDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0001-9136-9644
Monica H BoddDivision of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and.ORCID 0000-0003-4260-2125
Matthew J ReynoldsDivision of Hematology and Oncology, Department of Medicine, and.
Ashley M NelsonHarvard Medical School, Boston, MA.ORCID 0000-0003-1742-3280
Richard NewcombDivision of Hematology and Oncology, Department of Medicine, and.
Patrick Connor JohnsonDivision of Hematology and Oncology, Department of Medicine, and.ORCID 0000-0002-3943-6608
Tejaswini M DhawaleDivision of Hematology and Oncology, Department of Medicine, and.ORCID 0000-0003-0163-2061
Rachel PlotkeDivision of Hematology and Oncology, Department of Medicine, and.
Lauren HeuerDivision of Hematology and Oncology, Department of Medicine, and.
Sabah GillaniDivision of Hematology and Oncology, Department of Medicine, and.
Daniel YangDivision of Hematology and Oncology, Department of Medicine, and.
Emma C DearyDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA.
Elizabeth DaskalakisDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA.
Lauren GoldschenDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA.
Andrew BrunnerHarvard Medical School, Boston, MA.
Amir T FathiHarvard Medical School, Boston, MA.
Thomas W LeBlancDivision of Hematology and Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC; and.ORCID 0000-0002-0546-7895
Areej El-JawahriHarvard Medical School, Boston, MA.
Brigham and Women's Hospital · USHarvard University · USDuke University · US

Funding

A Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients.K08CA251654 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI AMONOO, HERMIONI L. · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA251654
6 · The paper itself

Abstract

Patients diagnosed with acute myeloid leukemia (AML) face sudden-onset life-threatening disease that requires intensive treatments. Although their early disease trajectory is characterized by significant, toxic side effects, limited data are available describing coping strategies among patients with AML and how these inform patient-reported outcomes. We used cross-sectional secondary data analyses to describe coping in 160 patients with newly diagnosed high-risk AML. The Brief COPE, Hospital Anxiety and Depression Scale, Post-Traumatic Stress Disorder Checklist-Civilian Version, and Functional Assessment of Cancer Therapy-Leukemia were used at time of AML diagnosis to measure coping strategies, psychological distress, and quality of life (QOL), respectively. The median split method for distribution of coping domains and multivariate regression models were used to assess the relationship between coping and patient-reported outcomes. Participants (median age, 64.4 years) were mostly non-Hispanic White (86.3%), male (60.0%), and married (73.8%). Most (51.9%) had high utilization of approach-oriented coping strategies, whereas 38.8% had high utilization of avoidant coping strategies. At time of diagnosis, use of approach-oriented coping was associated with less psychological distress (anxiety, β = -0.262, P = .002; depression symptoms, β = -0.311, P < .001; and posttraumatic distress disorder symptoms, β = -0.596, P = .006) and better QOL (β = 1.491, P = .003). Use of avoidant coping was associated with more psychological distress (anxiety, β = 0.884, P < .001; depression symptoms, β = 0.697, P < .001; and posttraumatic distress disorder symptoms, β = 3.048, P < .001) and worse QOL (β = -5.696, P < .001). Patients with high-risk AML use various approach-oriented and avoidant coping strategies at time of diagnosis. Use of approach-oriented coping strategies was associated with less psychological distress and better QOL, suggesting a possible target for supportive oncology interventions.

Indexed as

Leukemia, Myeloid, AcuteQuality of LifeAdaptation, PsychologicalAnxietyCross-Sectional StudiesHumansMaleMiddle Aged

Identifiers

PMID34768282
PMCPMC9006266
OpenAlexW3212595828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.