Evidence map›Paper›PMID 34768093›Full record

Trial reportJournal of communication disorders

Impairment of speech auditory feedback error detection and motor correction in post-stroke aphasia.

Stacey Sangtian, Yuan Wang, Julius Fridriksson, Roozbeh Behroozmand

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of communication disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  4. Effective neural connectivity deficits during speech auditory feedback processing in post-stroke aphasia: An fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  5. Neural pathways underlying the production of pitch and rhythm in aphasia.Annals of the New York Academy of Sciences · 2025
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  14. Aberrant modulation of broadband neural oscillations reflects vocal sensorimotor deficits in post-stroke aphasia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
    Article
  15. Aberrant beta-band brain connectivity predicts speech motor planning deficits in post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stacey SangtianSpeech Neuroscience Lab, Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, United States of America.
Yuan WangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, United States of America.
Julius FridrikssonAphasia Lab, Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, 915 Greene St., Columbia, SC 29208, United States of America; Center for the Study of Aphasia Recovery (C-STAR), Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, 915 Greene St., Columbia, SC 29208, United States of America.
Roozbeh BehroozmandSpeech Neuroscience Lab, Department of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, United States of America. Electronic address: r-behroozmand@sc.edu.
University of South Carolina · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Neural Bases of Vocal Sensorimotor Impairment in AphasiaR01DC018523 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI BEHROOZMAND, ROOZBEH · 2021 to 2025
$3.5M
Sensorimotor processing of auditory feedback in aphasiaK01DC015831 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BEHROOZMAND, ROOZBEH · 2017 to 2021
$693k
Speech Entrainment Treatment for Broca's AphasiaR21DC014170 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2015 to 2016
$403k
NIDCD NIH HHS K01 DC015831NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC018523NIDCD NIH HHS R21 DC014170
6 · The paper itself

Abstract

introductionThe present study investigated how damage to left-hemisphere brain networks affects the ability for speech auditory feedback error detection and motor correction in post-stroke aphasia.

methods34 individuals with left-hemisphere stroke and 25 neurologically intact age-matched control participants performed two randomized experimental tasks in which their online speech auditory feedback was altered using externally induced pitch-shift stimuli: 1) vocalization of a steady speech vowel sound /a/, and 2) listening to the playback of the same self-produced vowel vocalizations. Randomized control condition trials were interleaved in between vocalization and listening tasks where no pitch-shift stimuli were delivered. Following each trial, participants pressed a button to indicate whether they detected a pitch-shift error in their speech auditory feedback during vocalization and listening tasks.

resultsOur data analysis revealed that speech auditory feedback error detection accuracy rate was significantly lower in the stroke compared with control participants, irrespective of the experimental task (i.e. vocalization vs. listening) and trial condition (i.e. pitch-shifted vs. no-pitch-shift). We found that this effect was associated with the reduced magnitude of speech compensation in the early phase of responses at 150-200 ms following the onset of pitch-shift stimuli in stroke participants. In addition, motor speech compensation deficit in the stroke group was correlated with lower scores on speech repetition tasks as an index of language impairment resulting from aphasia.

conclusionsThese findings provide evidence that left-hemisphere stroke is associated with impaired speech auditory feedback error processing, and such deficits account for specific aspects of language impairment in aphasia.

Indexed as

AphasiaSpeechAcoustic StimulationFeedbackFeedback, SensoryHumansAphasiaAuditory feedbackSensorimotor integrationSpeech motor controlStroke

Identifiers

PMID34768093
PMCPMC8627481
OpenAlexW3209167247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.