Evidence map›Paper›PMID 34767855›Full record

ArticleJournal of neuroscience methods2022

Severe acute neurotoxicity reflects absolute intra-carotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine dose in non-human primates.

S A Norris, Hcb White, A Tanenbaum, E L Williams, C Cruchaga, L Tian, R E Schmidt, J S Perlmutter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

S A NorrisDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA; Departments of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA. Electronic address: norriss@wustl.edu.
Hcb WhiteDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
A TanenbaumDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
E L WilliamsDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
C CruchagaDepartments of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
L TianDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
R E SchmidtDepartments of Pathology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
J S PerlmutterDepartments of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA; Departments of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA; Departments of Neuroscience, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA; Departments of Physical, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA; Departments of Occupational Therapy, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONSR01NS058714 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2008 to 2016
$4.4M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISMR01NS050425 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2005 to 2009
$2.6M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
RESCUE FROM NIGROSTRIATAL INJURYR01NS039913 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2003
$1.2M
NINDS NIH HHS R01 NS039913NINDS NIH HHS R01 NS050425NINDS NIH HHS R01 NS058714NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS124789NINDS NIH HHS RF1 NS075321
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineMPTP PoisoningAnimalsCorpus StriatumPrimatesPyrrolidinesSubstantia Nigra1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinePyrrolidinesBasal gangliaMonkeyMPTPNeurotoxicityStriatum

Identifiers

PMID34767855
PMCPMC9673039
OpenAlexW3212335556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.