Observational studyChest2022
Significance of FEV
Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph
Observational study in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 34 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Incidence and Risk Factors for Progression from Pre-COPD to COPD: A Systematic Review and Meta‑analysis.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- Can assessment of small airway dysfunction support the diagnosis or management of asthma exacerbations in children? A systematic review.BMC pulmonary medicine · 2025Pooled it
- Can measures of small airway dysfunction aid with the diagnosis or management of asthma exacerbations? A systematic review.BMJ open respiratory research · 2025Pooled it
- The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study.Respiratory research · 2023Pooled it
- Expiratory time constant patterns reveal obstructive lung mechanics in non-obstructive spirometry.PLOS digital health · 2026Article
- Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Clinical Significance of Reduced Forced Expiratory Volume in 3 Seconds to Forced Expiratory Volume in 6 Seconds in Adults.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Review
- Small airways obstruction predicts cardiovascular disease incidence: a longitudinal study of UK Biobank.ERJ open research · 2026Article
- Pre-COPD: Impact on prevention, detection, and treatment.Presse medicale (Paris, France : 1983) · 2026Review
- Small Airways Disease in Patients With COPD: A Question-and-Answer Approach for Everyday Clinical Practice.Chest · 2026Review
- Small airway dysfunction: a shared, early, measurable, and potentially treatable trait across COPD, asthma, and fibrotic lung disease.Frontiers in medicine · 2026Review
- Association of forced expiratory volume in 0.5 seconds/forced vital capacity ratio with all-cause mortality in adults: a cohort study.Journal of thoracic disease · 2025Article
- Innovation in technologies for monitoring lung function in patients with respiratory disease.Breathe (Sheffield, England) · 2025Article
- Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China.Respiratory research · 2025Article
- Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.Annals of the American Thoracic Society · 2025Article
- The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study.BMJ open · 2025Article
- FEV1/FEV6 Cutoff Points to Avoid False Negatives When Using Portable Devices, PICO-6Journal of clinical medicine · 2025Article
- Early diagnostic and prognostic value of FEV₃/FEV₆ for COPD in underserved areas.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 14 institutions in 1 country.
Nathan YeeDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Daniela MarkovicDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Russell G BuhrDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; VA HSR&D Center for the Study of Healthcare Innovation, Implementation, and Policy, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA.
Spyridon FortisCenter for Access & Delivery Research & Evaluation, Iowa City VA Health Care System, Iowa City, IA; Department of Internal Medicine, Division of Pulmonary, Critical Care and Occupation Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Mehrdad ArjomandiDivision of Pulmonary Medicine, UCSF, San Francisco, CA.
David CouperDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Wayne H AndersonDepartment of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Robert PaineDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah, Salt Lake City, UT; Department of Veterans Affairs Medical Center, Salt Lake City, UT.
Prescott G WoodruffDivision of Pulmonary Medicine, UCSF, San Francisco, CA.
Meilan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.
Fernando J MartinezDivision of Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.
James M WellsDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
Victor E OrtegaSection on Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Eric A HoffmanDepartment of Radiology, Division of Physiologic Imaging, University of Iowa, Carver College of Medicine, Iowa City, IA.
Victor KimDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
M Bradley DrummondDepartment of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Russell P BowlerDepartment of Medicine, National Jewish Medical and Research Center, Denver, CO.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI; Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI.
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Donald P TashkinDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Igor Z BarjaktarevicDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: ibarjaktarevic@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USUniversity of California, San Francisco · USUniversity of Michigan–Ann Arbor · USCenter for the Study of Healthcare Provider Behavior · USColumbia University · USIowa City VA Health Care System · USTemple University · USUniversity of Alabama at Birmingham · USUniversity of Colorado Denver · USUniversity of Iowa · USVeterans Health Administration · USWake Forest University · USWeill Cornell Medicine · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MThe Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1MNRSA Training CoreTL1TR001883 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI, Nina Thawata Harawa · 2016 to 2026
$8.6MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MAZD9688: A First in Class Disease Modifying Therapy to Treat Alpha-1 Antitrypsin Deficiency a Genetically Linked Orphan DiseaseUH3TR002450 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ABAN, INMACULADA, DRANSFIELD, MARK T · 2018 to 2021
$4.5MMatrikines and COPD-PHR01HL148215 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2019 to 2023
$2.4MAlpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of DiseaseUG3HL152323 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M, STRANGE, CHARLTON B · 2020 to 2021
$1.7MHSRD VA CIN 13-412NCATS NIH HHS KL2 TR001882NCATS NIH HHS TL1 TR001883NCATS NIH HHS UH3 TR002450NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS R01 HL148215NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NHLBI NIH HHS UG3 HL152323NIEHS NIH HHS P30 ES005605
Abstract
backgroundSmall airways are known to be affected early in the course of COPD; however, traditional spirometric indices may not accurately identify small airways disease. RESEARCH QUESTION: Can forced expiratory volume in 3 s/forced expiratory volume in 6 s (FEV STUDY DESIGN AND
methodsThe study included 832 current and former smokers with post-bronchodilator FEV
resultsFEV
interpretationFEV CLINICAL
trial registrationClinicalTrials.gov; No.: NCT01969344; URL: www. CLINICALTRIALS: gov: ClinicalTrials.gov.
Indexed as
Pulmonary Disease, Chronic ObstructiveRespiration DisordersBronchodilator AgentsForced Expiratory VolumeHumansSmokersSpirometryVital CapacityBronchodilator AgentsCOPDearly airflow obstructionFEV(3)FEV(3)/FEV(6)FEV(6)small airways diseasespirometry
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.