Evidence map›Paper›PMID 34767769›Full record

ArticleNeuron2022

Molecular and functional architecture of striatal dopamine release sites.

Aditi Banerjee, Cordelia Imig, Karthik Balakrishnan, Lauren Kershberg, Noa Lipstein, Riikka-Liisa Uronen, Jiexin Wang, Xintong Cai, Fritz Benseler, Jeong Seop Rhee and 5 more

Open access · greenAbstract read
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  7. Review
  8. Article
  9. Review
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  11. Article
  12. Article
  13. Review
  14. The dopaminergic system ofRoyal Society open science · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Aditi BanerjeeDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Cordelia ImigDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Karthik BalakrishnanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Lauren KershbergDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Noa LipsteinDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Riikka-Liisa UronenDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Jiexin WangDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Xintong CaiDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Fritz BenselerDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Jeong Seop RheeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Benjamin H CooperDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Changliang LiuDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Sonja M WojcikDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kaeser@hms.harvard.edu.
Max Planck Institute of Experimental Medicine · DEHarvard University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2011 to 2020
$5.8M
Architecture and Function of Striatal Dopamine Signaling MachineryR01NS103484 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$4.7M
Mechanisms of Vesicle Docking and Priming for Striatal Dopamine ReleaseF31NS105159 · NINDS · HARVARD MEDICAL SCHOOL · PI KERSHBERG, LAUREN HAYLEY · 2018 to 2021
$96k
NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH113349NINDS NIH HHS F31 NS105159NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS103484
6 · The paper itself

Abstract

Despite the importance of dopamine for striatal circuit function, mechanistic understanding of dopamine transmission remains incomplete. We recently showed that dopamine secretion relies on the presynaptic scaffolding protein RIM, indicating that it occurs at active zone-like sites similar to classical synaptic vesicle exocytosis. Here, we establish using a systematic gene knockout approach that Munc13 and Liprin-α, active zone proteins for vesicle priming and release site organization, are important for dopamine secretion. Furthermore, RIM zinc finger and C

Indexed as

DopamineSynaptic TransmissionCorpus StriatumExocytosisSynapsesDopaminebasal gangliadopamineLiprin-αMunc13neuromodulationRIM1αRIM-BPsecretionstriatum

Identifiers

PMID34767769
PMCPMC8859508
OpenAlexW3214185212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.