Evidence map›Paper›PMID 34767637›Full record

ArticleImmunology2022

Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells.

Zhiguang Wu, Tuanjun Hu, Cosmin Chintoan-Uta, Joni Macdonald, Mark P Stevens, Helen Sang, David A Hume, Pete Kaiser, Adam Balic

Open access · hybridAbstract read
In one paragraph

Article in Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Evaluation of Immunoprotective Effects of DNA Vaccine Based onAnimals : an open access journal from MDPI · 2026
    Article
  2. Synergistic Enhancement ofAnimals : an open access journal from MDPI · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Development and function of chicken XCR1Frontiers in immunology · 2023
    Article
  10. Article
  11. Evolution and Potential Subfunctionalization of DuplicatedJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  12. Article
  13. Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhiguang WuThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Tuanjun HuThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Cosmin Chintoan-UtaThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Joni MacdonaldThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Mark P StevensThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Helen SangThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
David A HumeTranslational Research Institute, Mater Research Institute-University of Queensland, Woolloongabba, Qld, Australia.
Pete KaiserThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.
Adam BalicThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.ORCID 0000-0001-8369-7269
Roslin Institute · GBTranslational Research Institute · AU

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20320000Wellcome TrustWellcome Trust 099164/Z/12/Z
6 · The paper itself

Abstract

Conventional dendritic cells (cDC) are bone marrow-derived immune cells that play a central role in linking innate and adaptive immunity. cDCs efficiently uptake, process and present antigen to naïve T cells, driving clonal expansion of antigen-specific T-cell responses. In chicken, vital reagents are lacking for the efficient and precise identification of cDCs. In this study, we have developed several novel reagents for the identification and characterization of chicken cDCs. Chicken FLT3 cDNA was cloned and a monoclonal antibody to cell surface FLT3 was generated. This antibody identified a distinct FLT3

Indexed as

AnimalsAntibodies, MonoclonalBiomarkersCell Culture TechniquesChickensDendritic CellsFluorescent Antibody Techniquefms-Like Tyrosine Kinase 3Gene ExpressionHumansImmunophenotypingReceptors, G-Protein-CoupledReceptors, Granulocyte-Macrophage Colony-Stimulating FactorRecombinant Fusion ProteinsAntibodies, MonoclonalBiomarkersfms-Like Tyrosine Kinase 3Receptors, G-Protein-CoupledReceptors, Granulocyte-Macrophage Colony-Stimulating FactorRecombinant Fusion Proteinsavianchickenconventional dendritic cellCSF1RFLT3macrophagereagentsXCR1

Identifiers

PMID34767637
PMCPMC10357484
OpenAlexW3212181363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.