Evidence map›Paper›PMID 34767487›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Optimizing transesophageal atrial pacing in mice to detect atrial fibrillation.

Matthew B Murphy, Kyungsoo Kim, Prince J Kannankeril, Tuerdi Subati, Joseph C Van Amburg, Joey V Barnett, Katherine T Murray

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Animal and cellular models of atrial fibrillation: a review.Frontiers in cardiovascular medicine · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew B MurphyDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-2297-2703
Kyungsoo KimDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Prince J KannankerilDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-1529-9872
Tuerdi SubatiDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Joseph C Van AmburgDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Joey V BarnettDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-8757-4976
Katherine T MurrayDepartments of Medicine, Pediatrics, and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-1342-4457
Vanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Novel Pathophysiological Targets in Atrial Fibrillation SusceptibilityR01HL133127 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MURRAY, KATHERINE T · 2017 to 2020
$2.1M
Preamyloid Oligomers and Susceptibility to Atrial FibrillationR01HL096844 · NHLBI · VANDERBILT UNIVERSITY · PI MURRAY, KATHERINE T · 2010 to 2014
$1.9M
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS R01 HL096844NHLBI NIH HHS R01 HL133127
6 · The paper itself

Abstract

Mice are routinely used to investigate molecular mechanisms underlying the atrial fibrillation (AF) substrate. We sought to optimize transesophageal rapid atrial pacing (RAP) protocols for the detection of AF susceptibility in mouse models. Hypertensive and control C57Bl/6J mice were subjected to burst RAP at a fixed stimulus amplitude. The role of parasympathetic involvement in pacing-related atrioventricular (AV) block and AF was examined using an intraperitoneal injection of atropine. In a crossover study, burst and decremental RAP at twice diastolic threshold were compared for induction of AV block during pacing. The efficacy of burst and decremental RAP to elicit an AF phenotype was subsequently investigated in mice deficient in the lymphocyte adaptor protein (

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAtrial FibrillationEchocardiography, TransesophagealHeart RateHomeobox Protein PITX2Homeodomain ProteinsMaleMiceMice, Inbred C57BLReproducibility of ResultsTranscription FactorsAdaptor Proteins, Signal TransducingHomeobox Protein PITX2Homeodomain ProteinsLnk protein, mouseTranscription Factorsatrial fibrillationmouse modelsrapid atrial pacingtransesophageal atrial pacingtransesophageal pacing

Identifiers

PMID34767487
PMCPMC8698503
OpenAlexW3211607503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.