Evidence map›Paper›PMID 34767485›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Leveraging avidin-biotin interaction to quantify permeability property of microvessels-on-a-chip networks.

Feng Gao, Haoyu Sun, Xiang Li, Pingnian He

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Assessments of microvascular function in organ systems.American journal of physiology. Heart and circulatory physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Feng GaoDepartment of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.
Haoyu SunDepartment of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.
Xiang LiDepartment of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.ORCID 0000-0002-4916-524X
Pingnian HeDepartment of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.ORCID 0000-0001-7346-7419
Penn State Milton S. Hershey Medical Center · US

Funding

Red blood cell released ATP in disturbed blood flow-initiated site specific vascular inflammation and atherosclerosisR01HL144620 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2019 to 2022
$3.1M
Nitric oxide and microvessel permeability in vivoR01HL130363 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2017 to 2020
$1.9M
NHLBI NIH HHS R01 HL130363NHLBI NIH HHS R01 HL144620
6 · The paper itself

Abstract

Microvessels-on-a-chip have enabled in vitro studies to closely simulate in vivo microvessel environment. However, assessing microvessel permeability, a functional measure of microvascular exchange, has not been attainable in nonpermeable microfluidic platforms. This study developed a new approach that enables permeability coefficients (

Indexed as

AvidinBiotinCapillary PermeabilityLab-On-A-Chip DevicesAnimalsCalciumCells, CulturedEndothelial CellsEndothelium, VascularGlycocalyxMicrofluidicsMicrovesselsRatsAvidinBiotinCalciumapplication of avidin-biotin interactionglycocalyxmicrovessel permeabilitymicrovessels-on-a-chipsolute transport pathways

Identifiers

PMID34767485
PMCPMC8698539
OpenAlexW3212830029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.