ArticleScience advances2021
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- TMBIM6: at the intersection between proteostasis dysregulation and Parkinson's disease.Cell death and differentiation · 2026Article
- Global cellular responses to lysosomal damage.Current biology : CB · 2026Review
- pH-mediated activation of the lysosomal arginine sensor SLC38A9.FEBS letters · 2026Article
- Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Th17-related genes PGAP1 and TMBIM1 serve as potential diagnostic and predictive biomarkers in systemic sclerosis: bioinformatic identification and murine model validation.Clinical rheumatology · 2026Article
- Loss of Epithelial Homeostasis Driven by TMBIM1 Depletion via E-Cadherin Junction Disassembly.International journal of molecular sciences · 2026Article
- Lysosome-dependent cell death in hepatocellular carcinoma: unlocking the therapeutic potential of natural products.Frontiers in pharmacology · 2026Review
- pH-dependent regulation in SLC38A9.bioRxiv : the preprint server for biology · 2025Article
- An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance.Materials today. Bio · 2025Article
- Key Mechanisms in Lysosome Stability, Degradation and Repair.Molecular and cellular biology · 2025Review
- Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis.Frontiers in endocrinology · 2025Review
- The Golgi CaBiophysics reports · 2024Article
- Bone targeted nano-drug and nano-delivery.Bone research · 2024Review
- The ion channels of endomembranes.Physiological reviews · 2024Review
- A mechanism of lysosomal calcium entry.Science advances · 2024Article
- Programmed Cell Death in Unicellular Versus Multicellular Organisms.Annual review of genetics · 2023Review
- The evolution of organellar calcium mapping technologies.Cell calcium · 2022Review
- Proapoptotic RECS1: a requisite gateway to lysosomal dysfunction and death.Neural regeneration research · 2022Article
- TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.Life science alliance · 2022Article
- FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
28 authors at 11 institutions in 7 countries.
Funding
Abstract
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM1 (transmembrane BAX inhibitor motif containing 1)] as a proapoptotic member of the TMBIM family. In contrast to other proteins of the TMBIM family, RECS1 expression induces cell death through the canonical mitochondrial apoptosis pathway. Unbiased screening indicated that RECS1 sensitizes cells to lysosomal perturbations. RECS1 localizes to lysosomes, where it regulates their acidification and calcium content, triggering lysosomal membrane permeabilization. Structural modeling and electrophysiological studies indicated that RECS1 is a pH-regulated calcium channel, an activity that is essential to trigger cell death. RECS1 also sensitizes whole animals to stress in vivo in
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.