Evidence map›Paper›PMID 34767297›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA.

Suresh S Pujari, Caitlin C Jokipii Krueger, Christopher Chao, Spencer Hutchins, Alexander K Hurben, Gunnar Boysen, Natalia Tretyakova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Suresh S PujariDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Caitlin C Jokipii KruegerDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Christopher ChaoDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Spencer HutchinsDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Alexander K HurbenDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Gunnar BoysenDepartment of Environmental and Occupational Health and the Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 820, Little Rock, AR, 72205, USA.
Natalia TretyakovaDepartment of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-0621-6860
University of Minnesota · USWinthrop Rockefeller Foundation · US

Funding

DNA Cross-Linking By DiepoxybutaneR01CA100670 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2021
$3.5M
NCI NIH HHS R01 CA-100670NCI NIH HHS R01 CA100670
6 · The paper itself

Abstract

Metabolic activation of the human carcinogen 1,3-butadiene (BD) by cytochrome 450 monooxygenases gives rise to a genotoxic diepoxide, 1,2,3,4-diepoxybutane (DEB). This reactive electrophile alkylates guanine bases in DNA to produce N7-(2-hydroxy-3,4-epoxy-1-yl)-dG (N7-DE-dG) adducts. Because of the positive charge at the N7 position of the purine heterocycle, N7-DEB-dG adducts are inherently unstable and can undergo spontaneous depurination or base-catalyzed imidazole ring opening to give N

Indexed as

DNAEpoxy CompoundsButadienesChromatography, High Pressure LiquidDNA AdductsFormamidesFuransHumansPyrimidines1,3-butadieneButadienesdiepoxybutaneDNADNA AdductsEpoxy CompoundsFormamidesFuransN6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidinePyrimidines1,2,3,4-diepoxybutane1,3-ButadieneDEB-FAPy-dGDNAformamidopyrimidine

Identifiers

PMID34767297
PMCPMC10603587
OpenAlexW3211693491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.