Trial reportAging clinical and experimental research2022
Cognitive training program improves cognitive ability and daily living ability in elderly patients with mild cognitive impairment.
Trial report in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Feasibility of a short-term intensive home-based cognitive and physical training program for older adults: a single-arm pilot study.BMC geriatrics · 2026Article
- Influencing factors of health utility values in older adult people with normal cognition or mild cognitive impairment: a cross-sectional survey.Frontiers in public health · 2025Article
- Research progress of neuron-specific enolase in cognitive disorder: a mini review.Frontiers in human neuroscience · 2024Review
- Physical activity, sleep disorders, and type of work in the prevention of cognitive function decline in patients with hypertension.BMC public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild cognitive impairment (MCI) is a clinical syndrome of mild memory or other cognitive impairment without dementia and is a clinical transition state between normal aging and dementia. Careful and meticulous nursing intervention can improve the clinical symptoms of MCI and delay the progression of the disease.
aimsThis research aimed to evaluate the efficacy of cognitive function training interventions in elderly patients with MCI.
methods106 patients were randomized into the intervention group or the control group. They received conventional nursing intervention and those in the intervention group received additional cognitive training program for 6 weeks. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), activities of daily living (ADL) scales, and Barthel index (BI) were evaluated before and 6 weeks after the intervention, as well as the serum levels of S100β and neuron-specific enolase (NSE) at two time points.
resultsAfter intervention, the MMSE scores and MoCA scores in both groups were significantly increased and the score in the intervention group was significantly higher. In the intervention group, the performance of conventional nursing intervention and cognitive training program significantly increased the scores of ADL and BI (p < 0.001). The serum levels of NSE and S100β in the intervention group were significantly lower. DISCUSSION: The performance of cognitive training program alleviated the brain tissue damage in elderly patients with MCI.
conclusionsThe performance of cognitive training program in elderly patients with MCI improved their cognitive ability and daily living ability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.