ArticleWorld journal of pediatrics : WJP2022
Treatment status of extremely premature infants with gestational age < 28 weeks in a Chinese perinatal center from 2010 to 2019.
Article in World journal of pediatrics : WJP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Survival outcomes among periviable infants: a systematic review and meta-analysis comparing different income countries and time periods.Frontiers in public health · 2024Pooled it
- Hypertensive disorders of pregnancy contribute to developmental and metabolic multimorbidity in preterm infants.Nature communications · 2026Article
- Factors associated with survival of extremely preterm infants and development of a nomogram: a 9-year single-center study in China.Scientific reports · 2026Article
- [Expert recommendations on antenatal counseling for extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Enhanced Survival of 22-25 Week Preterm Infants After Proactive Care Implementation: A Comparative Analysis of Two Time Periods.Indian journal of pediatrics · 2025Article
- Risk assessment and early prediction of intraventricular hemorrhage in extremely preterm infants.Scientific reports · 2025Article
- The Chinese adverse prognosis of very preterm infants (CARE-Preterm) cohort: study design and baseline characteristics for a prospective multicenter cohort study.BMC pediatrics · 2025Article
- [Impact of different treatment attitudes on survival and risk factors for poor clinical outcomes in extremely preterm infants: a retrospective real-world study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- A real-world study on the treatment of extremely preterm infants: a multi-center study in southwest area of Fujian Province in China.BMC pediatrics · 2024Article
- Article
- A nomogram for predicting death for infants born at a gestational age of <28 weeks: a population-based analysis in 18 neonatal intensive care units in northern China.Translational pediatrics · 2023Article
- Determining resuscitation threshold for extremely preterm infants based on the survival rates without severe neurological injury.Journal of global health · 2023Article
- Differences in the attitudes towards resuscitation of extremely premature infants between neonatologists and obstetricians: a survey study in China.Frontiers in pediatrics · 2023Article
- Obstetricians' Attitudes Toward the Treatment of Extremely Preterm Infants in China.JAMA network open · 2022Article
- Risk factors that affect the degree of bronchopulmonary dysplasia in very preterm infants: a 5-year retrospective study.BMC pediatrics · 2022Article
- Association between pulmonary hemorrhage and CPAP failure in very preterm infants.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is a paucity of studies conducted in China on the outcomes of all live-birth extremely premature infants (EPIs) and there is no unified recommendation on the active treatment of the minimum gestational age in the field of perinatal medicine in China. We aimed to investigate the current treatment situation of EPIs and to provide evidence for formulating reasonable treatment recommendations.
methodsWe established a real-world ambispective cohort study of all live births in delivery rooms with gestational age (GA) between 24
resultsOf the 1163 EPIs included in our study, 241 (20.7%) survived, while 849 (73.0%) died in the delivery room and 73 (6.3%) died in the neonatal intensive care unit. Among all included EPIs, 862 (74.1%) died from withholding or withdrawal of care. Regardless of stratification according to GA or birth weight, the proportion of total mortality attributable to withdrawal of care is high. For infants with the GA of 24 weeks, active treatment did not extend their survival time (P = 0.224). The survival time without severe morbidity of the active treatment was significantly longer than that of withdrawing care for infants older than 25 weeks (P < 0.001). Over time, the survival rate improved, and the withdrawal of care caused by socioeconomic factors and primary nonintervention were reduced significantly (P < 0.001).
conclusionsThe mortality rate of EPIs is still high. Withdrawal of care is common for EPIs with smaller GA, especially in the delivery room. It is necessary to use a multi-center, large sample of real-world data to find the survival limit of active treatment based on our treatment capabilities.
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