ReviewCurrent osteoporosis reports2021
Osteocytes and Weightlessness.
Review in Current osteoporosis reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Microgravity-Induced Osteocyte Dysfunction: An Osteocyte Mechanobiology Unit Framework.Current osteoporosis reports · 2026Review
- Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion.Communications medicine · 2026Article
- Irisin Prevents the Effects of Simulated Microgravity on Bone and Muscle Differentiation Markers.FASEB bioAdvances · 2025Article
- Tensile force promotes osteogenic differentiation via ephrinB2-EphB4 signaling pathway in orthodontic tooth movement.BMC oral health · 2025Article
- Effects ofWorld journal of gastroenterology · 2025Article
- Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis.Frontiers in cell and developmental biology · 2025Review
- Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.NPJ microgravity · 2024Article
- Article
- Vibration Rather than Microgravity Affects Bone Metabolism in Adult Zebrafish Scale Model.Cells · 2024Article
- Simulated microgravity increases CD226Physiological reports · 2024Article
- Osteocyte Mechanotransduction in Orthodontic Tooth Movement.Current osteoporosis reports · 2023Review
- Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration.NPJ microgravity · 2023Review
- Single Cell in a Gravity Field.Life (Basel, Switzerland) · 2022Review
- Bone-kidney axis: A potential therapeutic target for diabetic nephropathy.Frontiers in endocrinology · 2022Review
- Impact of the host response and osteoblast lineage cells on periodontal disease.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewOsteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions or in simulated microgravity conditions models on Earth. RECENT
findingsAfter a brief recall of the main changes in bone mass and osteoclastic and osteoblastic activities in space-related models, this review focuses on the potential role of osteocytes in directing these changes. The role of the best-known signalling molecules is questioned, in particular in relation to osteocyte apoptosis. The mechanotransduction actors identified in spatial conditions and the problems related to fluid flow and shear stress changes, probably enhanced by the alteration in fluid flow and lack of convection during spaceflight, are recalled and discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.