Evidence map›Paper›PMID 34767106›Full record

Article3D printing in medicine2021

3D printed customised external cranial plate in a patient with syndrome of trephined: 'a case report'.

Mee H, Greasley S, Whiting G, Harkin C, Oliver G, Marsden D, Andrews R, Sireau S, Price Rd, Anwar F and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3D printing in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mee HDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. harrymee@nhs.net.
Greasley SClinical Engineering Innovation Team, Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Whiting GDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Harkin CDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Oliver G3D visualisation and printing department, Media Studios, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Marsden DClinical Engineering Innovation Team, Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Andrews RClinical Engineering Innovation Team, Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sireau SClinical Engineering Innovation Team, Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Price RdDepartment of Plastic and Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Anwar FDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Timofeev IsDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Hutchinson PjDepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
White PaClinical Engineering Innovation Team, Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Helmy ADepartment of Clinical Neurosciences, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Cambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyndrome of the trephined is a well-recognised phenomenon that occurs in patients following a craniectomy. It is associated with several symptoms, including headaches, motor impairments, cognitive disorders and reduced consciousness. Treatment for the syndrome usually involves replacing the skull defect. CASE STUDY: A 71-year-old male underwent a left-sided craniectomy after being diagnosed with biopsy-confirmed invasive squamous cell carcinoma with associated skull erosion. Subsequently, he developed a severe case of syndrome of the trephined (SoT,) resulting in having to lie flat to prevent the motor component of the Glasgow Coma Score (GCS) falling from M5/6 (E3/4 Vt M5/6) to M1 (E3/4 Vt M1) on sitting to 30 degrees. Unfortunately, due to ongoing chest sepsis and physical frailty, he was unable to undergo a cranioplasty. Therefore, to aid in clinical stabilisation, the treating physicians and clinical engineering teams designed and manufactured a prosthesis on-site, allowing rapid patient treatment. The prosthesis led to the patient being able to sit up to 30 degrees without the motor component of the GCS falling from M6 to M1 (E4 VT M6).

conclusionClinical improvements were demonstrated with definitive neurological improvement after applying the external cranial plate in clinical outcome measures and radiographically. Furthermore, we have shown that rapid prototyping technology provides a flexible solution to synthesise bespoke medical prostheses with the correct expertise and regulatory framework.

Identifiers

PMID34767106
PMCPMC8588646
OpenAlexW3202890597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.