Evidence map›Paper›PMID 34767045›Full record

ArticleCancer immunology, immunotherapy : CII2022

Distribution, phenotype, functional and clinical relevance of CD8

Yang Shen, Xiao-Long Li, Yu-Xian Li, Zhi-Guo Shan, Yong-Liang Zhao, Ping Cheng, Zhuo Zhao, Jin-Yu Zhang, Weisan Chen, Yuan Zhuang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. CD8MedComm · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Cell Identity and Spatial Distribution of PD-1/PD-L1 Blockade Responders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Review
  9. Article
  10. CD39 expression defines exhausted CD4Clinical & translational immunology · 2024
    Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yang Shen *National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Xiao-Long Li *Department of General Surgery of Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Yu-Xian LiNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Zhi-Guo ShanDepartment of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Yong-Liang ZhaoDepartment of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Ping ChengNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Zhuo ZhaoNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Jin-Yu ZhangNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Weisan ChenLa Trobe Institute for Molecular Science, School of Molecular Science, La Trobe University, Bundoora, VIC, 3085, Australia.
Yuan ZhuangNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Dai-Yuan MaDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan Province, China.
Quan-Ming ZouNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yuan QiuDepartment of General Surgery of Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China. xiaoq2037@qq.com.
Liu-Sheng PengNational Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. pengliusheng06@163.com.ORCID http://orcid.org/0000-0002-8798-6006
Army Medical University · CNAffiliated Hospital of North Sichuan Medical College · CNLa Trobe University · AU

Funding

national natural science foundation of china 81773042national natural science foundation of china 81872331
6 · The paper itself

Abstract

CD8

Indexed as

Stomach NeoplasmsCD8-Positive T-LymphocytesHumansImmunologic MemoryIntegrin alpha ChainsLymphocytes, Tumor-InfiltratingMemory T CellsPhenotypeProgrammed Cell Death 1 ReceptorIntegrin alpha ChainsProgrammed Cell Death 1 Receptor4-1BBCD8+CD103+ tissue-resident memory T cellsGastric cancerPD-1

Identifiers

PMID34767045
PMCPMC10992218
OpenAlexW3213628234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.