Evidence map›Paper›PMID 34766923›Full record

ArticleAging2021

Low-protein diet applied as part of combination therapy or stand-alone normalizes lifespan and tumor proliferation in a model of intestinal cancer.

Alina Proske, Judith Bossen, Jakob von Frieling, Thomas Roeder

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Time-Restricted Feeding Promotes Longevity and Gut Health Without Fitness Trade-Offs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alina ProskeDepartment of Molecular Physiology, Zoological Institute, Kiel University, Kiel, Germany.
Judith BossenDepartment of Molecular Physiology, Zoological Institute, Kiel University, Kiel, Germany.
Jakob von FrielingDepartment of Molecular Physiology, Zoological Institute, Kiel University, Kiel, Germany.
Thomas RoederDepartment of Molecular Physiology, Zoological Institute, Kiel University, Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DEGerman Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumors of the intestinal tract are among the most common tumor diseases in humans, but, like many other tumor entities, show an unsatisfactory prognosis with a need for effective therapies. To test whether nutritional interventions and a combination with a targeted therapy can effectively cure these cancers, we used the fruit fly

Indexed as

Diet, Protein-RestrictedIntestinal NeoplasmsAnimalsAntineoplastic AgentsCaloric RestrictionCell ProliferationDrosophila melanogasterFemaleLongevityProtein Kinase InhibitorsAntineoplastic AgentsProtein Kinase Inhibitorsafatinibcancerdietary protein restrictionDrosophilaEGFRstem cells

Identifiers

PMID34766923
PMCPMC8610115
OpenAlexW3212629137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.