Evidence map›Paper›PMID 34766905›Full record

ArticleeLife2021

A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.

Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Michele L Lemons, Jeremy Florman, Christopher M Lambert, Denis Touroutine, Kellianne Alexander, Liliane Schoofs, Mark J Alkema and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Axon termination of the SAB motor neurons inbioRxiv : the preprint server for biology · 2025
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  10. GPCR Sense Communication Among Interaction Nematodes with Other Organisms.International journal of molecular sciences · 2025
    Review
  11. Review
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  15. Article
  16. Article
  17. A molecular atlas of adultbioRxiv : the preprint server for biology · 2023
    Article
  18. Peptidomics.Nature reviews. Methods primers · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Shankar Ramachandran *Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0002-1299-4482
Navonil Banerjee *Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Raja Bhattacharya *Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Michele L LemonsDepartment of Biological and Physical Sciences, Assumption University, Worcester, United States.ORCID 0000-0001-8459-4130
Jeremy FlormanDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0001-7578-3511
Christopher M LambertDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Denis TouroutineDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Kellianne AlexanderDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.
Liliane SchoofsDepartment of Biology, University of Leuven (KU Leuven), Leuven, Belgium.
Mark J AlkemaDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0002-1311-5179
Isabel BeetsDepartment of Biology, University of Leuven (KU Leuven), Leuven, Belgium.
Michael M FrancisDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0002-8076-6668
University of Massachusetts Chan Medical School · USKU Leuven · BE

Funding

Molecular Analysis of Neural Circuit Excitation and InhibitionR01NS064263 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRANCIS, MICHAEL M · 2009 to 2025
$5.5M
The gut brain axis: microbial impact on neural functionR01NS107475 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK · 2018 to 2022
$1.8M
The impact of stress neurohormones on health and agingR01GM140480 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK · 2021 to 2024
$1.5M
Neuromodulator signaling and context-dependent behaviorR21NS093492 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRANCIS, MICHAEL M · 2015 to 2016
$461k
NIGMS NIH HHS R01 GM140480NINDS NIH HHS R01 NS064263NINDS NIH HHS R01 NS107475NINDS NIH HHS R21 NS093492
6 · The paper itself

Abstract

Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here, we show that the

Indexed as

Adaptation, PsychologicalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsLocomotionNeuropeptidesReceptors, G-Protein-CoupledCaenorhabditis elegans Proteinsckr-1 protein, C elegansckr-2 protein, C elegansNeuropeptidesReceptors, G-Protein-CoupledC. eleganscholecystokininG protein-coupled receptorlocal searchneural circuitsneuropeptideneuroscience

Identifiers

PMID34766905
PMCPMC8626090
OpenAlexW3212007923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.