Evidence map›Paper›PMID 34766790›Full record

Trial reportEmotion (Washington, D.C.)2022

Autonomic reactivity to social rejection, peer difficulties, and the buffering effects of adolescent friendships following early psychosocial deprivation.

Alva Tang, Katie A McLaughlin, Margaret A Sheridan, Charles A Nelson, Charles H Zeanah, Nathan A Fox

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Emotion (Washington, D.C.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alva TangDepartment of Human Development and Quantitative Methodology.ORCID 0000-0003-2552-0419
Katie A McLaughlinDepartment of Psychology.
Margaret A SheridanDepartment of Psychology.
Charles A NelsonBoston Children's Hospital.
Charles H ZeanahDepartment of Psychiatry.ORCID 0000-0002-7004-6819
Nathan A FoxDepartment of Human Development and Quantitative Methodology.
Quantitative BioSciences · USBoston Children's Hospital · US

Funding

Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
The Relation Between Early Psychosocial Deprivation and Mental Health at 12 YearsR01MH091363 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A, NELSON, CHARLES ALEXANDER · 2010 to 2024
$9.2M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
Binder Family FoundationJacobs FoundationJohn D. and Catherine T. MacArthur FoundationNICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH091363NIMH NIH HHS R01 MH106482NIMH NIH HHS R37 MH119194Palix Foundation
6 · The paper itself

Abstract

Autonomic nervous system reactivity has been posited to be a mechanism contributing to social and emotional problems among children exposed to early adversity. Leveraging data from the Bucharest Early Intervention Project, a longitudinal randomized controlled trial of foster care versus institutional care of abandoned children in Romania, we assessed whether altered sympathetic reactivity to peer rejection feedback in early adolescence mediated the relation between early institutional rearing and peer problems in later adolescence. We also assessed whether adolescent friendship quality or randomized placement in foster care early in life moderated these associations. Participants include 68 institutionalized children randomized to care as usual, 68 institutionalized children randomized to foster care, and 135 never-institutionalized children. At age 12, participants reported friendship quality with respect to a best friend and completed a social rejection task while electrocardiogram and impedance cardiography were recorded. Sympathetic nervous system reactivity to rejection feedback was assessed using preejection period (PEP). At ages 12 and 16, peer problems were reported by parents. Mediation analysis revealed that less PEP reactivity to social rejection at age 12 partially mediated the association between early institutionalization and greater peer problems at age 16. Further moderated mediation analysis revealed that this indirect effect was evidenced among previously institutionalized youths with low, but not high, quality friendships. We did not observe foster care intervention effects. These findings suggest that altered sympathetic reactivity to social rejection might be a mechanism linking early institutionalization to social difficulties into adolescence, however, positive adolescent friendships may buffer these effects. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

FriendsPsychosocial DeprivationAdolescentAutonomic Nervous SystemChildChild, InstitutionalizedHumansSocial Status

Identifiers

PMID34766790
PMCPMC9661887
OpenAlexW3214058873

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.