Evidence map›Paper›PMID 34766649›Full record

ArticleBritish journal of pharmacology2022

Sexual dimorphism in prostacyclin-mimetic responses within rat mesenteric arteries: A novel role for K

Samuel N Baldwin, Elizabeth A Forrester, Lauren McEwan, Iain A Greenwood

Open access · hybridAbstract read
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Identification of Sodium/Myo-Inositol Transporter 1 as a Major Determinant of Arterial Contractility.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samuel N BaldwinMolecular and Clinical Sciences Research Institute, St. George's University, London, UK.ORCID 0000-0002-3796-6090
Elizabeth A ForresterMolecular and Clinical Sciences Research Institute, St. George's University, London, UK.ORCID 0000-0002-2164-103X
Lauren McEwanMolecular and Clinical Sciences Research Institute, St. George's University, London, UK.ORCID 0000-0002-1983-2574
Iain A GreenwoodMolecular and Clinical Sciences Research Institute, St. George's University, London, UK.ORCID 0000-0002-0603-0492
St George's, University of London · GB

Funding

British Heart Foundation FS/18/41/33762
6 · The paper itself

Abstract

background and purposeProstacyclin mimetics express potent vasoactive effects via prostanoid receptors that are not unequivocally defined, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of IP and EP EXPERIMENTAL APPROACH: Within second-order mesenteric arteries from male and female Wistar rats, we determined (1) relative mRNA transcripts for EP KEY

resultsIloprost evoked a biphasic response in male mesenteric arteries, at concentrations ≤100 nmol·L CONCLUSIONS AND IMPLICATIONS: Stark sexual dimorphisms in iloprost-mediated vasoactive responses are present within mesenteric arteries. K

Indexed as

EpoprostenolKCNQ1 Potassium ChannelSex CharacteristicsAnimalsFemaleIloprostInositol 1,4,5-Trisphosphate ReceptorsMaleMesenteric ArteriesRatsRats, WistarReceptors, EpoprostenolReceptors, ProstaglandinEpoprostenolIloprostInositol 1,4,5-Trisphosphate ReceptorsKCNQ1 Potassium ChannelReceptors, EpoprostenolReceptors, ProstaglandinGPCRIloprostKv7MRE-269ProstacyclinSexVascular

Identifiers

PMID34766649
PMCPMC9340493
OpenAlexW3212388298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.