Evidence map›Paper›PMID 34766579›Full record

ArticleMedicine2021

A case report of cryoablation and electrochemotherapy in kidney cancer.

Giovanni Mastrandrea, Carmelo Laface, Vito Fazio, Marco Lopetuso, Gianmarco Falagario, Pasquale Molinari, Girolamo Ranieri, Cosmo Damiano Gadaleta

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Reversible electroporation for cancer therapy.The British journal of radiology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Giovanni MastrandreaAnaesthesia, Resuscitation and Postoperative Intensive Care Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.ORCID 0000-0002-0241-5117
Carmelo LafaceInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.
Vito FazioInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.
Marco LopetusoDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Gianmarco FalagarioInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.
Pasquale MolinariInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.
Girolamo RanieriInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.ORCID 0000-0001-8779-1957
Cosmo Damiano GadaletaInterventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari, Italy.
Istituto Tumori Bari · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAccording to scientific literature, cryoablation (CA) and electrochemotherapy (ECT) have been used for the treatment of small renal masses. However, no data have been published regarding the combination of these techniques as therapy of primary kidney cancers. Therefore, we report the case of an old woman affected by localized kidney cancer and discuss the potential therapeutic application of CA combined with subsequent deep ECT in this setting. PATIENT CONCERNS: An 85 years-old-woman was evaluated because of a localized kidney cancer. Her background history included long-time hypertension and diabetes mellitus in drug treatment. DIAGNOSES: In February 2018, the follow-up contrast enhancement computed tomography (ceCT) documented a suspected 18×10 mm metastasis at the lower right lobe of the lung. The ceCT also showed a suspected primary malignancy of 25×18 mm at right kidney.

interventionsThe kidney cancer was treated with a two-phase procedure: percutaneous CA and subsequent deep ECT. OUTCOMES: Patient obtained a complete response according to modified Response Evaluation Criteria in Solid Tumors, without renal function or quality of life impairment. No procedure-related complications were observed. Moreover, a shorter period of hospitalization and convalescence were needed respect to standard surgery. No sign of relapse was observed during follow-up period. LESSONS: This combined strategy proved to be safe and effective. Moreover, the application of these blended loco-regional techniques showed several other advantages such as reduced hospitalization and a shorter period of convalescence respect to standard surgery.

Indexed as

CryosurgeryElectrochemotherapyKidney NeoplasmsAged, 80 and overConvalescenceFemaleHumansNeoplasm Recurrence, LocalQuality of LifeTreatment Outcome

Identifiers

PMID34766579
PMCPMC10545287
OpenAlexW3214281131

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.