ArticleClinical trials (London, England)2021
Incentives and payments in pragmatic clinical trials: Scientific, ethical, and policy considerations.
Article in Clinical trials (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06419868 (Acceptability and Feasibility of a Universal Preventive Intervention for Depression and Anxiety in University Students), which is not on this map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acceptability and Feasibility of a Universal Preventive Intervention for Depression and Anxiety in University Students
Who cites it
4 citing papers in PubMed.
- Trial
- Clinical trial awareness and participation attitudes among patients with epidermolysis bullosa and their caregivers: a nationwide cross-sectional study from Saudi Arabia.Frontiers in medicine · 2026Article
- Evaluating acute image ordering for real-world patient cases via language model alignment with radiological guidelines.Communications medicine · 2025Article
- Toward Meeting the Obligation of Respect for Persons in Pragmatic Clinical Trials.The Hastings Center report · 2022Article
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3 authors.
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Abstract
Pragmatic clinical trials are increasingly used to generate knowledge about real-world clinical interventions. However, they involve some distinctive ethical and regulatory challenges. In this article, we examine a set of issues related to incentives and other payments to patients in pragmatic clinical trials. Although many of the ethical concerns related to incentives and payments in explanatory trials pertain to pragmatic clinical trials, the pragmatic features may introduce additional challenges. These include those related to the risk of incentives and payments undermining the scientific validity and social value of pragmatic clinical trials, the sources of data used in pragmatic clinical trials, and when the pragmatic clinical trials are conducted under waivers of consent. Based on our examination of these matters, we offer some preliminary recommendations regarding incentives and payments in pragmatic clinical trials, recognizing that additional data and experiences are needed to refine them.
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