Evidence map›Paper›PMID 34766515›Full record

ArticlePhysiological genomics2022

Systems genetics analysis defines importance of TMEM43/

Qingqing Gu, Fuyi Xu, Buyan-Ochir Orgil, Zaza Khuchua, Undral Munkhsaikhan, Jason N Johnson, Neely R Alberson, Joseph F Pierre, Dennis D Black, Deli Dong and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Physiological genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Circulation research · 2025
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  14. Review
  15. Article
  16. Article
  17. Expression Levels of theInternational journal of molecular sciences · 2023
    Article
  18. TheAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  19. Article
  20. Highlighting recent impactful publications inPhysiological genomics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Qingqing GuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Fuyi XuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Buyan-Ochir OrgilDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Zaza KhuchuaThe Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Undral MunkhsaikhanDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0002-7241-9172
Jason N JohnsonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Neely R AlbersonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Joseph F PierreDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Dennis D BlackDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Deli DongDepartment of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China.
Jaclyn A BrennanDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Brianna M CatheyDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.
Igor R EfimovDepartment of Biomedical Engineering, The George Washington University, Washington, District of Columbia.ORCID 0000-0002-1483-5039
Jeffrey A TowbinDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Enkhsaikhan PurevjavDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-6188-7176
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
University of Tennessee Health Science Center · USGeorge Washington University · USBinzhou Medical University · CNCincinnati Children's Hospital Medical Center · USHarbin Medical University · CNSt. Jude Children's Research Hospital · US

Funding

Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL128350NHLBI NIH HHS R01 HL151438
6 · The paper itself

Abstract

Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated with transmembrane protein43 (TMEM43/

Indexed as

Arrhythmogenic Right Ventricular DysplasiaMembrane ProteinsAnimalsHeartMiceMutationPhenotypeMembrane ProteinsBXD familycardiomyopathygene networksystems geneticsTMEM43/LUMA

Identifiers

PMID34766515
PMCPMC8721901
OpenAlexW3213908852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.