ArticleBirth defects research2022
Prevalence of neural tube defects, maternal HIV status, and antiretroviral therapy from a hospital-based birth defect surveillance in Kampala, Uganda.
Article in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub-Saharan Africa.Birth defects research · 2026Article
- Incidental Prenatal Discovery of Anencephaly via Portable Ultrasounds in a Remote Medical Care Setting.Cureus · 2025Article
- Cohort profile: measuring adverse pregnancy and newborn congenital outcomes (MANGO) study in Kenya.BMJ open · 2025Article
- Risk of Adverse Birth Outcomes and Birth Defects Among Women Living With HIV on Antiretroviral Therapy and HIV-Negative Women in Uganda, 2015-2021.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Neural tube defect among newborns in public hospitals of Tigray region, northern Ethiopia: A cross-sectional study.PloS one · 2025Article
- Article
- Population-based prevalence of congenital defects in a routine sentinel site-based surveillance system in the Western Cape, South Africa.Birth defects research · 2024Article
- The Aperta type of neural tube defect: The relevant experience in a local community with the diversity of the presentation.Journal of medicine and life · 2023Article
- Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis.International journal of pediatrics · 2023Review
- The value of midwifery counseling during lactation as a key factor of pharmacovigilance.European journal of midwifery · 2022Article
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15 authors.
Funding
Abstract
backgroundThe estimated prevalence of neural tube defects (NTDs) in Africa is 11.7 per 10,000 live births; however, data on the impact of antiretroviral therapy (ART) during pregnancy and the risk for birth defects in Africa are limited.
methodsData from a hospital-based surveillance program at four hospitals in Kampala, Uganda were used to estimate the baseline prevalence of NTDs and assess potential associations with HIV status and ART use. All live births, stillbirths, and spontaneous abortions delivered at the participating hospitals affected with selected birth defects between August 2015 and December 2018 were included. Trained midwives collected data from hospital records, maternal interviews, photographs, and narrative descriptions of birth defects. We estimated NTD prevalence per 10,000 births (live, stillbirths, spontaneous abortions), prevalence ratios, and 95% confidence intervals (CIs).
resultsA total of 110,752 births from 107,133 women were included in the analysis; 9,394 (8.8%) women were HIV-infected and among those with HIV infection, 95.6% (n = 8,977) were on ART at delivery. Overall, 109 births were affected with NTDs, giving a prevalence of 9.8 (95% CI [8.2, 11.9]). Spina bifida (n = 63) was the most common type of NTD, with a prevalence of 5.7 (95% CI [4.4, 7.3]), followed by anencephaly (n = 31), with a prevalence of 2.8 (95% CI [2.0, 4.0]).
conclusionThe prevalence of NTDs among births in Kampala, Uganda is consistent with current estimates for Africa. With the continued introduction of new medications that may be taken during pregnancy, sustainable birth defect surveillance systems and pharmacovigilance are indicated.
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