Evidence map›Paper›PMID 34766285›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Synthesis of Cell-Penetrating Peptide Coated Silica Nanoparticles and Their Physicochemical and Biological Characterization.

Isabel Gessner, Annika Klimpel, Ines Neundorf

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isabel GessnerDepartment of Chemistry, Institute of Inorganic Chemistry, University of Cologne, Cologne, Germany.
Annika KlimpelDepartment of Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany.
Ines NeundorfDepartment of Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany. ines.neundorf@uni-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surface decoration of nanoparticles with cell-penetrating peptides (CPPs) represents a common technique for intracellular delivery of nanotherapeutics. Conjugate formation can be performed via covalent or non-covalent strategies. Here, we describe on the synthesis of silica nanoparticles, a well-known inorganic drug delivery vehicle type, and their surface modification with cell-penetrating peptides using sC18 and derivatives thereof. Moreover, physicochemical as well as biological characterization methods, including cellular uptake measurements, of particle-peptide conjugates are described.

Indexed as

NanoparticlesCell-Penetrating PeptidesDrug Delivery SystemsSilicon DioxideCell-Penetrating PeptidesSilicon DioxideCell-penetrating peptidesCellular uptakeInternalizationNanoparticlesParticle-peptide conjugateSurface modification

Identifiers

PMID34766285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.