Evidence map›Paper›PMID 34766280›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2022

Shuttling Homeoproteins and Their Biological Significance.

Alain Prochiantz, Ariel A Di Nardo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alain ProchiantzDevelopment and Neuropharmacology Group, Center for Interdisciplinary Research in Biology, Collège de France, Paris Cedex 05, France. alain.prochiantz@college-de-france.fr.
Ariel A Di NardoDevelopment and Neuropharmacology Group, Center for Interdisciplinary Research in Biology, Collège de France, Paris Cedex 05, France.
Collège de France · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transfer of homeoprotein transcription factors is at the origin of the discovery of Penetratin, one of the first transduction peptides allowing for the addressing of hydrophilic cargoes to the cell cytoplasm and nucleus. Beyond this important technological application, homeoprotein transduction has now been confirmed for more than 150 members of this family, and represents an intriguing mode of signaling for which actual in vivo functions are known for a handful of these proteins. Because homeoproteins are expressed in all eukaryotes, and their intercellular transfer occurs both in plants and animals, it is likely that this signaling activity appeared before the separation between plants, fungi, and animals, and is therefore very ancient. These aspects are discussed in the present review, with an accent placed on evolution and on the comparison of homeoprotein signaling between species belonging to distinct phyla.

Indexed as

AnimalsCell CommunicationCell NucleusHomeodomain ProteinsSignal TransductionTranscription FactorsHomeodomain ProteinsTranscription FactorsEvolutionHomeoproteinsSignalingTranscription factors

Identifiers

PMID34766280
OpenAlexW3212190597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.