Evidence map›Paper›PMID 34766247›Full record

ArticleMolecular imaging and biology2022

Repurposing [

Amanda J Boyle, Andrea Narvaez, Junchao Tong, Sami S Zoghbi, Victor W Pike, Robert B Innis, Neil Vasdev

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. RadiolabeledFrontiers in nuclear medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Amanda J BoyleAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada. amy.boyle@camh.ca.
Andrea NarvaezAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada.
Junchao TongAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada.
Sami S ZoghbiNational Institute of Mental Health, Bethesda, MD, USA.
Victor W PikeNational Institute of Mental Health, Bethesda, MD, USA.
Robert B InnisNational Institute of Mental Health, Bethesda, MD, USA.
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada. neil.vasdev@utoronto.ca.ORCID 0000-0002-2087-5125
Centre for Addiction and Mental Health · CANational Institute of Mental Health · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
PET Radiopharmaceutical SciencesZ01MH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2002 to 2008
$7.4M
Preclinical Evaluation Of PET RadiotracersZ01MH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2002 to 2008
$3.2M
Intramural NIH HHS Z01 MH002793Intramural NIH HHS Z01 MH002795Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795Intramural NIH HHS ZIA MH002852
6 · The paper itself

Abstract

purposeCyclooxygenase-2 (COX-2) is a target for inflammation and colorectal cancer (CRC). This study evaluated the COX-2 neuro-PET radiopharmaceutical, [ PROCEDURES: [

resultsHT-29 xenografts were well visualized with [

conclusions[

Indexed as

Colorectal NeoplasmsPositron-Emission TomographyAnimalsCell Line, TumorCyclooxygenase 2HeterograftsHumansMiceTissue DistributionCyclooxygenase 2Carbon-11Colorectal cancerCOX-2Cyclooxygenase-2InflammationPET

Identifiers

PMID34766247
PMCPMC9670325
OpenAlexW3213166136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.