Evidence map›Paper›PMID 34766235›Full record

ArticleJournal of assisted reproduction and genetics2021

Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016-2018.

Kathryn D Sanders, Giuseppe Silvestri, Tony Gordon, Darren K Griffin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Article
  7. Review
  8. Review
  9. In vitro fertilization as an option for couples with genetic disorders.Clinical and experimental reproductive medicine · 2025
    Article
  10. Review
  11. PGT-A: what's it for, what's wrong?Journal of assisted reproduction and genetics · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Preimplantation genetic testing for aneuploidy: predictive embryonic factors.Journal of assisted reproduction and genetics · 2024
    Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kathryn D SandersSchool of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.ORCID http://orcid.org/0000-0002-4774-5347
Giuseppe SilvestriSchool of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.ORCID http://orcid.org/0000-0002-5496-2470
Tony GordonCooperGenomics, London, UK.ORCID http://orcid.org/0000-0003-2756-1943
Darren K GriffinSchool of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK. D.K.Griffin@kent.ac.uk.ORCID http://orcid.org/0000-0001-7595-3226
University of Kent · GBGenomics England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the live birth and other outcomes reported with and without preimplantation genetic testing for aneuploidy (PGT-A) in the United Kingdom (UK) Human Embryology and Fertilization Authority (HFEA) data collection.

methodsA retrospective cohort analysis was conducted following freedom of information (FoI) requests to the HFEA for the PGT-A and non-PGT-A cycle outcomes for 2016-2018. Statistical analysis of differences between PGT-A and non-PGT-A cycles was performed. Other than grouping by maternal age, no further confounders were controlled for; fresh and frozen transfers were included.

resultsOutcomes collected between 2016 and 2018 included total number of cycles, cycles with no embryo transfer, total number of embryos transferred, live birth rate (LBR) per embryo transferred and live birth rate per treatment cycle. Data was available for 2464 PGT-A out of a total 190,010 cycles. LBR per embryo transferred and LBR per treatment cycle (including cycles with no transfer) were significantly higher for all PGT-A vs non-PGT-A age groups (including under 35), with nearly all single embryo transfers (SET) after PGT-A (significantly more in non-PGT-A) and a reduced number of transfers per live birth particularly for cycles with maternal age over 40 years.

conclusionThe retrospective study provides strong evidence for the benefits of PGT-A in terms of live births per embryo transferred and per cycle started but is limited in terms of matching PGT-A and non-PGT-A cohorts (e.g. in future studies, other confounders could be controlled for). This data challenges the HFEA "red traffic light" guidance that states there is "no evidence that PGT-A is effective or safe" and hence suggests the statement be revisited in the light of this and other new data.

Indexed as

AdultAneuploidyBirth RateBlastocystFemaleFertilizationFertilization in VitroGenetic TestingHumansLive BirthMaternal AgePregnancyPregnancy RatePreimplantation DiagnosisRetrospective StudiesUnited KingdomPreimplantation genetic testing aneuploidyRetrospective study

Identifiers

PMID34766235
PMCPMC8666405
OpenAlexW3211660348

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.