Evidence map›Paper›PMID 34766232›Full record

ArticleJournal of computer-aided molecular design2021

Design of new imidazole derivatives with anti-HCMV activity: QSAR modeling, synthesis and biological testing.

Vasyl Kovalishyn, Volodymyr Zyabrev, Maryna Kachaeva, Kostiantyn Ziabrev, Kathy Keith, Emma Harden, Caroll Hartline, Scott H James, Volodymyr Brovarets

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vasyl KovalishynV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Murmanska Str, Kyiv, 02094, Ukraine. vkovalishyn@gmail.com.ORCID 0000-0002-9352-7332
Volodymyr ZyabrevV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Murmanska Str, Kyiv, 02094, Ukraine.
Maryna KachaevaV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Murmanska Str, Kyiv, 02094, Ukraine.
Kostiantyn ZiabrevInstitute of Organic Chemistry, National Academy of Sciences, 5, Murmanska Str, Kyiv, 02660, Ukraine.
Kathy KeithDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
Emma HardenDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
Caroll HartlineDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
Scott H JamesDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
Volodymyr BrovaretsV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Murmanska Str, Kyiv, 02094, Ukraine.

Funding

NIAID NIH HHS HHSN75N93019D00016
6 · The paper itself

Abstract

The problem of designing new antiviral drugs against Human Cytomegalovirus (HCMV) was addressed using the Online Chemical Modeling Environment (OCHEM). Data on compound antiviral activity to human organisms were collected from the literature and uploaded in the OCHEM database. The predictive ability of the regression models was tested through cross-validation, giving coefficient of determination q

Indexed as

CytomegalovirusQuantitative Structure-Activity RelationshipAnti-Bacterial AgentsAntiviral AgentsHumansImidazolesMachine LearningAnti-Bacterial AgentsAntiviral AgentsImidazolesAntiviral activityHuman cytomegalovirus (HCMV)Imidazole derivativesMachine learningOCHEM

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.