Evidence map›Paper›PMID 34766209›Full record

ReviewLung2021

Twenty-Year Reflection on the Impact of World Trade Center Exposure on Pulmonary Outcomes in Fire Department of the City of New York (FDNY) Rescue and Recovery Workers.

Krystal L Cleven, Carla Rosenzvit, Anna Nolan, Rachel Zeig-Owens, Sophia Kwon, Michael D Weiden, Molly Skerker, Allison Halpren, David J Prezant

Abstract readReview
In one paragraph

Review in Lung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Association of COVID-19 Severity with Comorbidities: Results from the World Trade Center Health Registry.International journal of environmental research and public health · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Long-Term Physical-Psychiatric Comorbidities Related to Childhood Exposure to 9/11 Trauma.International journal of environmental research and public health · 2024
    Article
  11. Article
  12. Article
  13. Mutagenicity of the organic fraction of World Trade Center dust.Environmental and molecular mutagenesis · 2023
    Article
  14. Article
  15. Article
  16. The Role of Personality in the Mental and Physical Health of World Trade Center Responders: Self- versus Informant-Reports.Clinical psychological science : a journal of the Association for Psychological Science · 2022
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krystal L ClevenPulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA. kcleven@montefiore.org.ORCID 0000-0002-6921-9743
Carla RosenzvitPulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Anna NolanThe Bureau of Health Services and the FDNY World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.
Rachel Zeig-OwensPulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Sophia KwonPulmonary, Critical Care and Sleep Medicine Division, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Michael D WeidenThe Bureau of Health Services and the FDNY World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.
Molly SkerkerPulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Allison HalprenThe Bureau of Health Services and the FDNY World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.
David J PrezantPulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.

Funding

Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary InterventionU01OH011300 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2017 to 2025
$4.8M
World Trade Center Particulate Matter Induced Cardiorespiratory and Vascular Dysfunction: a MultiOmic ApproachU01OH011855 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2021 to 2025
$3.0M
Aerodigestive Disease in the World Trade Center Exposed FDNY Cohort: Validation of Biomarkers and Defining Risk to Tailor TherapyU01OH012069 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2021 to 2025
$2.2M
RAGE Mediates LPA Induced Pulmonary InflammationR01HL119326 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2015 to 2019
$2.1M
NHLBI NIH HHS R01 HL119326NIOSH CDC HHS U01 OH011300NIOSH CDC HHS U01 OH011855NIOSH CDC HHS U01 OH012069
6 · The paper itself

Abstract

After the terrorist attacks on September 11, 2001 (9/11), many rescue/recovery workers developed respiratory symptoms and pulmonary diseases due to their extensive World Trade Center (WTC) dust cloud exposure. Nearly all Fire Department of the City of New York (FDNY) workers were present within 48 h of 9/11 and for the next several months. Since the FDNY had a well-established occupational health service for its firefighters and Emergency Medical Services workers prior to 9/11, the FDNY was able to immediately start a rigorous monitoring and treatment program for its WTC-exposed workers. As a result, respiratory symptoms and diseases were identified soon after 9/11. This focused review summarizes the WTC-related respiratory diseases that developed in the FDNY cohort after 9/11, including WTC cough syndrome, obstructive airways disease, accelerated lung function decline, airway hyperreactivity, sarcoidosis, and obstructive sleep apnea. Additionally, an extensive array of biomarkers has been identified as associated with WTC-related respiratory disease. Future research efforts will not only focus on further phenotyping/treating WTC-related respiratory disease but also on additional diseases associated with WTC exposure, especially those that take decades to develop, such as cardiovascular disease, cancer, and interstitial lung disease.

Indexed as

Emergency Medical ServicesFirefightersOccupational ExposureSeptember 11 Terrorist AttacksHumansLungNew York9/11Lung injuryObstructive airways diseaseOccupational exposureWorld trade center

Identifiers

PMID34766209
PMCPMC8583580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.