Evidence map›Paper›PMID 34766191›Full record

ArticleNeuroradiology2022

Association between carotid artery dissection and vascular tortuosity: a case-control study.

Gabriele Venturini, Luisa Vuolo, Giovanni Pracucci, Antonella Picchioni, Ylenia Failli, Federica Benvenuti, Cristina Sarti

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In one paragraph

Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gabriele VenturiniNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.ORCID http://orcid.org/0000-0003-1199-7312
Luisa VuoloNeuroradiology Unit, Careggi University Hospital, Largo Piero Palagi, 1, 50139, Florence, Italy.
Giovanni PracucciNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
Antonella PicchioniNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
Ylenia FailliNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
Federica BenvenutiNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
Cristina SartiNEUROFARBA Department, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy. cristina.sarti@unifi.it.ORCID http://orcid.org/0000-0002-8409-4782
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to verify if vascular tortuosity (VT) may represent a risk factor for spontaneous epiaortic vessel dissection (sEVD) in young adult patients.

methodsWe identified 304 patients aged under 55 years consecutively admitted for acute cerebrovascular events to our Stroke Unit. After checking the possibility to perform a 3D reconstruction of epiaortic vessels on CT-angiography images, we selected and compared fifty patients with sEVD (cases) with fifty-one patients without dissection (controls). VT of carotid and vertebral arteries was measured on reconstructions evaluating the vascular tortuosity index (VTI), calculated according to a specific algorithm, and the presence of kinking and coiling. Differences between groups were analyzed by Student-t test for numeric variables and chi-square test for categoric ones. A ROC curve analysis was used to look for a VTI threshold value beyond which the risk of dissection was significantly increased.

resultsVTI was significantly higher in cases than in controls only considering carotid arteries (p = 0.029); cases did not have a significantly higher rate of kinking and coiling than controls (p = 0.059 and 0.077, respectively). We have found a significant VTI threshold value of 27.9% (under curve area = 61.6%, p = 0.04) only for carotid artery dissection.

conclusionVT appears to be associated with an increased risk of dissection for the carotid district but not for the vertebral one. The different structure, embryogenesis, and pathophysiology of dissection between the two districts could explain this finding. VTI threshold as carotid artery dissection predictor deserves confirmation in larger studies.

Indexed as

Aortic DissectionCarotid Artery DiseasesAgedCarotid ArteriesCarotid Artery, InternalCase-Control StudiesHumansVertebral ArteryYoung AdultComputed tomography angiographyEpiaortic vessel dissectionStrokeVascular tortuosityYoung adult

Identifiers

PMID34766191
OpenAlexW3213456800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.