ReviewMedComm2021
Biodegradable magnesium-based biomaterials: An overview of challenges and opportunities.
Review in MedComm, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 225 citations in OpenAlex.
- Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications.Bioactive materials · 2027Review
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Synergistic Effects of Magnesium Ions and Hydrogen Gas in Biodegradable Mg Implants: Mechanisms, Therapeutic Windows, and Translational Perspectives.Annals of biomedical engineering · 2026Review
- Reconstructing the ischemic osteogenic microenvironment through hierarchical scaffolds orchestrating MgBioactive materials · 2026Article
- Using Magnesium and Magnesium-Based Alloys as a Novel Biomaterial to Create Medical Devices by AM Techniques-A Review.Materials (Basel, Switzerland) · 2026Review
- Tribocorrosion Behavior of Mg Alloys on Sliding Friction in Hank's Balanced Salt Solution.Materials (Basel, Switzerland) · 2026Article
- Author's reply to the Letters regarding "Failure analysis and design improvement of retrieved plates from revision surgery".Journal of orthopaedic translation · 2026Article
- Article
- pH-Responsive mPEG-PLGA/Dexamethasone Coatings for Corrosion Control and Osteo-Immune Modulation of Biodegradable Magnesium.Polymers · 2026Article
- One-year clinical outcomes after fixation of condylar head fractures using a reduced-head PEO-modified WE43 biodegradable magnesium screw.Frontiers in oral health · 2026Article
- Emerging Nanomaterials Can Even Treat Chronic Wounds: A Review of Evidence on Magnesium-Based Systems.International journal of nanomedicine · 2026Review
- Synergistic effects of biodegradable magnesium alloy and erythromycin on osteogenic activity.Journal of dental sciences · 2026Article
- Development of biodegradable Mg-Zn-Zr-based temporary implant materials through multidirectional forging and laser shock peening.Scientific reports · 2025Article
- Effect of powder particle concentration, pulse duration, and pulse current on machined surface characterization produced via EDM of biocompatible WE-43Mg alloy.Scientific reports · 2025Article
- Functional and three-dimensional radiographic outcomes after open reduction and internal fixation of condylar head fractures using magnesium alloy cannulated screws - a retrospective long-term follow-up.Clinical oral investigations · 2025Observational
- Strontium-Zinc conversion coating on magnesium plates for resorbable tack screws in guided bone regeneration: Characterization and biocompatibility evaluation.Journal of clinical and experimental dentistry · 2025Article
- The Influence of Zn and Ca Addition on the Microstructure, Mechanical Properties, Cytocompatibility, and Electrochemical Behavior of WE43 Alloy Intended for Orthopedic Applications.Medicina (Kaunas, Lithuania) · 2025Article
- Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head.Materials today. Bio · 2025Review
- Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment.Bioactive materials · 2025Article
- Towards Correlative Raman Spectroscopy-STEM Investigations Performed on a Magnesium-Silver Alloy FIB Lamella.Nanomaterials (Basel, Switzerland) · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As promising biodegradable materials with nontoxic degradation products, magnesium (Mg) and its alloys have received more and more attention in the biomedical field very recently. Having excellent biocompatibility and unique mechanical properties, magnesium-based alloys currently cover a broad range of applications in the biomedical field. The use of Mg-based biomedical devices eliminates the need for biomaterial removal surgery after the healing process and reduces adverse effects induced by the implantation of permanent biomaterials. However, the high corrosion rate of Mg-based implants leads to unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. To overcome these limitations, alloying Mg with suitable alloying elements and surface treatment come highly recommended. In this area, open questions remain on the behavior of Mg-based biomaterials in the human body and the effects of different factors that have resulted in these challenges. In addition to that, many techniques are yet to be verified to turn these challenges into opportunities. Accordingly, this article aims to review major challenges and opportunities for Mg-based biomaterials to minimize the challenges for the development of novel biomaterials made of Mg and its alloys.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.