Evidence map›Paper›PMID 34766124›Full record

ReviewMedComm2020

The biological role of metabolic reprogramming in pancreatic cancer.

Tatsunori Suzuki, Motoyuki Otsuka, Takahiro Seimiya, Takuma Iwata, Takahiro Kishikawa, Kazuhiko Koike

Abstract readReview
In one paragraph

Review in MedComm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Understanding the Conundrum of Pancreatic Cancer in the Omics Sciences Era.International journal of molecular sciences · 2024
    Review
  13. Article
  14. The role of GOT1 in cancer metabolism.Frontiers in oncology · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tatsunori SuzukiDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.
Motoyuki OtsukaDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0003-2869-2881
Takahiro SeimiyaDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.
Takuma IwataDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.
Takahiro KishikawaDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.
Kazuhiko KoikeDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications.

Indexed as

autophagymacropinocytosismetabolismpancreatic cancertumor microenvironment

Identifiers

PMID34766124
PMCPMC8491225

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.