Evidence map›Paper›PMID 34766118›Full record

ArticleMedComm2020

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma

Yuanfang Huang, Guangfu Zeng, Qian Xin, Jinmei Yang, Cheng Zeng, Kexin Tang, Sheng-Tao Yang, Xiaohai Tang

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in MedComm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06048367 (Carbon Nanoparticle-Loaded Iron [CNSI-Fe), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06048367 phase1completednot on this mapstarted 2022, after this paper: background citation

Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] Dose Escalation Study for the Treatment of Advanced Solid Tumors: Phase 1 Clinical Trial

TypeinterventionalSponsorSichuan Enray Pharmaceutical Sciences CompanyRan2022 to 2025Enrolled19ConditionsAdvanced Solid Tumor, Lung Cancer, Pancreas Cancer, Breast CancerArmsCNSI-Fe(II) 30 mg, CNSI-Fe(II) 60 mg, CNSI-Fe(II) 90 mg, CNSI-Fe(II) 120 mg, CNSI-Fe(II) 150 mg
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuanfang HuangSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
Guangfu ZengSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
Qian XinSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
Jinmei YangSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
Cheng ZengSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
Kexin TangCollege of Chemistry and Environment Protection Engineering Southwest Minzu University Chengdu P. R. China.
Sheng-Tao YangCollege of Chemistry and Environment Protection Engineering Southwest Minzu University Chengdu P. R. China.
Xiaohai TangSichuan Enray Pharmaceutical Sciences Company Chengdu P. R. China.
China National Pharmaceutical Group Corporation (China) · CNSouthwest Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the unique structure, carbon nanomaterials could convert near-infrared (NIR) light into heat efficiently in tumor ablation using photothermal therapy (PTT). Carbon nanoparticles suspension injection (CNSI) is a commercial imaging reagent for lymph node mapping. CNSI has similar structural characteristics to other carbon nanomaterials, and thus, might be applied as photothermal agent. Herein, we evaluated the photothermal conversion ability and therapeutic effects of CNSI on thyroid carcinoma. CNSI was composed by carbon nanoparticle cores and polyvinylpyrrolidone K30 as the dispersion reagent. CNSI absorbed NIR light efficiently following the Lambert-Beer law. The temperature of CNSI dispersion increased quickly under the NIR irradiation. CNSI killed the TCP-1 thyroid carcinoma cells under 808 nm laser irradiation at 0.5 W/cm

Indexed as

carbon nanoparticlesphotothermal therapytemperature controltheranosticstumor

Identifiers

PMID34766118
PMCPMC8491229
OpenAlexW3084704128

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.