Evidence map›Paper›PMID 34766108›Full record

ReviewMedComm2020

Engineered biomaterials for cancer immunotherapy.

Lulu Cai, Jialu Xu, Zhenglin Yang, Rongsheng Tong, Ziliang Dong, Chao Wang, Kam W Leong

Abstract readReview
In one paragraph

Review in MedComm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  5. Immune Cell Homing Hydrogels for Cancer Immunotherapy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lulu CaiPersonalized Drug Therapy Key Laboratory of Sichuan Province Department of Pharmacy Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China.
Jialu XuInstitute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University Suzhou China.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study the Institute of Laboratory Medicine Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China.
Rongsheng TongPersonalized Drug Therapy Key Laboratory of Sichuan Province Department of Pharmacy Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China.
Ziliang DongInstitute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University Suzhou China.
Chao WangInstitute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University Suzhou China.
Kam W LeongDepartment of Biomedical Engineering Columbia University New York USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although cancer immunotherapy is showing tremendous promise and has progressed to the clinic, it has only achieved sporadic efficacy, with only a fraction of patients benefitting from the therapy and with undesirable side effects due to poor selectivity and high doses. Localized delivery of immunomodulators to activate anticancer immunity in situ avoids overactivation of the systemic immune system and reduces side effects. Engineered biomaterials-implantable, injectable, or transdermal-fabricated into drug delivery devices are critical components for the development of localized cancer immunotherapies. In this review, we briefly summarize progress in the application of engineered biomaterials to the localized delivery of cancer immunotherapy.

Indexed as

anticancer immunitybiomaterialscancer immunotherapylocalized delivery

Identifiers

PMID34766108
PMCPMC8489675

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.