Evidence map›Paper›PMID 34766000›Full record

ArticleMolecular biomedicine2020

Multimodality molecular imaging of the alveolar-capillary barrier in lung disease using albumin based optical and PET tracers.

Andrei Molotkov, Nikunj Bhatt, Mikhail Doubrovin, John Castrillon, Christopher Massa, Adam Gerber, Jeanine D'Armiento, Monica Goldklang, Akiva Mintz

Open access · diamondAbstract read
In one paragraph

Article in Molecular biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. The bronchoalveolar lavage dilution conundrum: an updated view on a long-standing problem.American journal of physiology. Lung cellular and molecular physiology · 2024
    Review
  3. Review
  4. Advances in Preclinical PET.Seminars in nuclear medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andrei MolotkovDepartment of Radiology, Columbia University Irving Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Nikunj BhattDepartment of Radiology, Columbia University Irving Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Mikhail DoubrovinDepartment of Radiology, Columbia University Irving Medical Center, 722 W. 168th St., New York, NY 10032 USA.
John CastrillonDepartment of Radiology, Columbia University Irving Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Christopher MassaCenter for LAM and Rare Lung Diseases, Department of Anesthesiology, Columbia University Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Adam GerberCenter for LAM and Rare Lung Diseases, Department of Anesthesiology, Columbia University Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Jeanine D'ArmientoCenter for LAM and Rare Lung Diseases, Department of Anesthesiology, Columbia University Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Monica GoldklangCenter for LAM and Rare Lung Diseases, Department of Anesthesiology, Columbia University Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Akiva MintzDepartment of Radiology, Columbia University Irving Medical Center, 722 W. 168th St., New York, NY 10032 USA.
Columbia University Irving Medical Center · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NCATS NIH HHS UL1 TR001873
6 · The paper itself

Abstract

Inflammatory changes caused by viruses, bacteria, exposure to toxins, commonly used drugs and even surgical intervention have the potential of causing abnormal epithelial permeability, which is manifest as infiltrative processes on computed tomography (CT), including the widespread infiltrates seen in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS). We utilized a previously published mouse model of ARDS, intranasal delivery of LPS, to induce the alveolar-capillary barrier permeability seen in lung disease. We intravenously injected mice with Cy7 or 68-Gallium (

Indexed as

68Ga-albuminARDSCOVIDPET

Identifiers

PMID34766000
PMCPMC7749789
OpenAlexW3116480204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.