Evidence map›Paper›PMID 34765980›Full record

ArticleCritical care explorations2021

Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis.

Navin P Boeddha, Gertjan J Driessen, Nienke N Hagedoorn, Daniela S Kohlfuerst, Clive J Hoggart, Angelique L van Rijswijk, Ebru Ekinci, Debby Priem, Luregn J Schlapbach, Jethro A Herberg and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 8 countries.

Navin P BoeddhaIntensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Gertjan J DriessenDepartment of Paediatrics, Maastricht University Medical Center, Maastricht, The Netherlands.
Nienke N HagedoornDepartment of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Daniela S KohlfuerstDepartment of General Paediatrics, Medical University of Graz, Graz, Austria.
Clive J HoggartSection of Pediatrics, Imperial College London, London, United Kingdom.
Angelique L van RijswijkLaboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Ebru EkinciDepartment of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Debby PriemDepartment of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Luregn J SchlapbachChild Health Research Center, The University of Queensland, Brisbane, QLD, Australia.
Jethro A HerbergSection of Pediatrics, Imperial College London, London, United Kingdom.
Ronald de GrootRadboudumc Technology Center Clinical Studies, Radboudumc, Nijmegen, The Netherlands.
Suzanne T AndersonMRC Unit The Gambia at the LSHTM, Banjul, The Gambia.
Colin G FinkMicropathology Ltd, University of Warwick Science Park, Venture Centre, Coventry, United Kingdom.
Enitan D CarrolInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Michiel van der FlierPaediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, UMC Utrecht, Utrecht, The Netherlands.
Federico Martinón-TorresTranslational Pediatrics and Infectious Diseases Section, Pediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Michael LevinSection of Pediatrics, Imperial College London, London, United Kingdom.
Frank W LeebeekDepartment of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Werner ZenzDepartment of General Paediatrics, Medical University of Graz, Graz, Austria.
Moniek P M de MaatDepartment of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jan A HazelzetDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Marieke EmontsPaediatric Infectious Diseases and Immunology Department, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Willem A DikLaboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Erasmus MC - Sophia Children’s Hospital · NLErasmus MC · NLImperial College London · GBMedical University of Graz · ATIcahn School of Medicine at Mount Sinai · USMaastricht University · NLRadboud University Nijmegen · NLUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceA Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking.

objectivesTo study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome.

designData from two prospective cohort studies. SETTING AND

participantsCohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission). MAIN OUTCOMES AND MEASURES: Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay.

resultsIn cohort 1 ( CONCLUSIONS AND RELEVANCE: In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 and should study pathophysiologic mechanisms.

Indexed as

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 proteinbacterial infectionsbiomarkersinflammationmortalitysepsis

Identifiers

PMID34765980
PMCPMC8577672
OpenAlexW3211400374

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.