Evidence map›Paper›PMID 34765967›Full record

ReviewInternational journal of pharmaceutics: X2021

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases.

Luca Palugan, Matteo Cerea, Micol Cirilli, Saliha Moutaharrik, Alessandra Maroni, Lucia Zema, Alice Melocchi, Marco Uboldi, Ilaria Filippin, Anastasia Foppoli and 1 more

Abstract readReview
In one paragraph

Review in International journal of pharmaceutics: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Intravesical Delivery of P21 mRNA-Loaded Lipid Nanoparticles as a Tumor Suppressor Replacement Therapy for Bladder Cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Towards 4D printing in pharmaceutics.International journal of pharmaceutics: X · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luca PaluganDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Matteo CereaDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Micol CirilliDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Saliha MoutaharrikDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Alessandra MaroniDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Lucia ZemaDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Alice MelocchiDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Marco UboldiDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Ilaria FilippinDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Anastasia FoppoliDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.
Andrea GazzanigaDipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "M.E. Sangalli", Università degli Studi di Milano, via G. Colombo 71, Milano 20133, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diseases of the urinary bladder have high incidence rates and burden healthcare costs. Their pharmacological treatment involves systemic and local drug administration. The latter is generally accomplished through instillation of liquid formulations and requires repeated or long-term catheterization that is associated with discomfort, inflammation and bacterial infections. Consequently, compliance issues and dropouts are frequently reported. Moreover, instilled drugs are progressively diluted as the urine volume increases and rapidly excreted. When penetration of drugs into the bladder wall is needed, the poor permeability of the urothelium has also to be accounted for. Therefore, much research effort is spent to overcome these hurdles, thereby improving the efficacy of available therapies. Particularly, indwelling delivery systems suited for

Indexed as

3D and 4D printingBladderControlled releaseExpandable systemsIntravesical delivery

Identifiers

PMID34765967
PMCPMC8569723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.