Evidence map›Paper›PMID 34765727›Full record

ArticleAACE clinical case reports

A Rare Case of Familial Neurogenic Diabetes Insipidus in a 22-Year-Old Man.

Van T T Phan, Zachary W Bloomer, Vien T X Phan, Mohamed K M Shakir, Thanh D Hoang

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in AACE clinical case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Van T T PhanDivision of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Zachary W BloomerDivision of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Vien T X PhanDivision of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Mohamed K M ShakirDivision of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Thanh D HoangDivision of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Walter Reed National Military Medical Center · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDiabetes insipidus (DI) can be classified into 2 types: central/neurogenic DI and nephrogenic DI. Most cases of central DI occur after brain surgery, trauma, tumor, or infection. Here we report a rare case of familial central DI due to a heterozygous

methodsA case of familial neurogenic DI has been described with thorough clinical, laboratory, and genetic workup. PubMed and Google scholar databases were used for literature discussion.

resultsA 22-year-old man presented with polyuria and polydipsia. He drank about 4 gallons of water everyday and urinated large volumes very frequently. His physical examination was unremarkable. After 2 hours of water-deprivation, his serum sodium level was 147 mmol/L, serum osmolality was 302 mOsm/kg with concurrent urine osmolality of 78 mOsm/kg, vasopressin level was <0.8 pg/mL, and copeptin level was <2.8 pmol/L, suggesting neurogenic DI. His brain magnetic resonance imaging revealed the absence of the posterior pituitary bright spot but a normal anterior pituitary gland. Genetic analysis revealed a nonfunctional heterozygous mutation in the

conclusionGenetic mutations in the

Indexed as

AVP, arginine vasopressinAVP geneCDI, central diabetes insipiduscentral diabetes insipidusdesmopressinDI, diabetes insipidusER, endoplasmic reticulumfamilial diabetes insipidusMRI, magnetic resonance imagingNPII, neurophysin IIpolydipsiapolyuriaPosm, plasma osmolalityUosm, urine osmolality

Identifiers

PMID34765727
PMCPMC8573270
OpenAlexW3116173640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.