Evidence map›Paper›PMID 34765699›Full record

ArticleNeurobiology of stress2021

Neurochemically distinct populations of the bed nucleus of stria terminalis modulate innate fear response to weak threat evoked by predator odor stimuli.

Biborka Bruzsik, Laszlo Biro, Klara Rebeka Sarosdi, Dora Zelena, Eszter Sipos, Huba Szebik, Bibiána Török, Eva Mikics, Mate Toth

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  14. A sex-specific role for the bed nucleus of the stria terminalis in proactive defensive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Biborka BruzsikLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
Laszlo BiroLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
Klara Rebeka SarosdiLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
Dora ZelenaLaboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary.
Eszter SiposLaboratory of Behavioural and Stress Studies, Institute of Experimental Medicine, Budapest, Hungary.
Huba SzebikLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
Bibiána TörökJanos Szentagothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary.
Eva MikicsLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
Mate TothLaboratory of Translational Behavioural Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.
HUN-REN Institute of Experimental Medicine · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety and trauma-related disorders are characterized by significant alterations in threat detection, resulting in inadequate fear responses evoked by weak threats or safety stimuli. Recent research pointed out the important role of the bed nucleus of stria terminalis (BNST) in threat anticipation and fear modulation under ambiguous threats, hence, exaggerated fear may be traced back to altered BNST function. To test this hypothesis, we chemogenetically inhibited specific BNST neuronal populations (corticotropin-releasing hormone - BNST

Indexed as

AnxietyBed nucleus of stria terminalisDefensive responseInnate fearPredator scentThreat detection

Identifiers

PMID34765699
PMCPMC8572958
OpenAlexW3208641722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.