ArticleFrontiers in cellular and infection microbiology2021
Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Comparison of calcium hydroxide removal efficiency of ethylenediaminetetraacetic acid, phytic acid and N-acetylcysteine using sonic activation: a micro-CT study.BMC oral health · 2025Article
- Antimicrobial Effects of Tannic Acid Combined with Plasma-Activated Water and Their Application in Strawberry Preservation.Foods (Basel, Switzerland) · 2025Article
- On the Potential Role of Phytate Against Neurodegeneration: It Protects Against FeInternational journal of molecular sciences · 2025Article
- Antibiotic-potentiating efficacy ofFrontiers in pharmacology · 2025Article
- Effect of phytic acid on chemical, structural, and mechanical characteristics of nickel-titanium endodontic files.Scientific reports · 2024Article
- Oracle of phytic acid in dental panacea - Insight into properties, therapeutic effect, regeneration, materials interaction and oral physiology.The Saudi dental journal · 2024Article
- Is a mix - A fix? "A microscopic analysis of depth of penetration of three combinations of irrigants".Journal of conservative dentistry and endodontics · 2024Article
- Potential of phytic acid in synergy with sodium chloride as a natural-borne preservative to inactivateCurrent research in food science · 2024Article
- Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility.Pharmaceutics · 2023Article
- Phytic Acid Demonstrates Rapid Antibiofilm Activity and Inhibits Biofilm Formation When Used as a Surface Conditioning Agent.Microbiology spectrum · 2023Article
- Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview.Biomolecules · 2023Review
- Phytate Intake, Health and Disease: "Let Thy Food Be Thy Medicine and Medicine Be Thy Food".Antioxidants (Basel, Switzerland) · 2023Review
- A study on Sr/Zn phytate complexes: structural properties and antimicrobial synergistic effects against Streptococcus mutans.Scientific reports · 2022Article
- One-Step Preparation of Carboxymethyl Cellulose-Phytic Acid Hydrogels with Potential for Biomedical Applications.Gels (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Phytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. Recently, IP6 was proposed as a potential chelating agent in endodontics. However, there is limited knowledge regarding its antimicrobial and antibiofilm effectiveness. The aims of this study, were therefore to evaluate the antimicrobial and antibiofilm activities of IP6 against a range of microbial species and compare these with ethylenediaminetetraacetic acid (EDTA) and sodium hypochlorite (NaOCl). The contact time required for IP6 to exert its bactericidal effect on Methods: The inhibitory and biocidal activities of IP6, EDTA and NaOCl were assessed using a broth microdilution assay against 11 clinical and reference strains of bacteria and a reference strain of Results: IP6 was biocidal against all tested microorganisms. At concentrations of 0.5%, 1% and 2%, IP6 required 5 min to exert a bactericidal effect on
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.