Evidence map›Paper›PMID 34765544›Full record

ArticleFrontiers in oncology2021

Oncogenic Integration of Nucleotide Metabolism

Dashnamoorthy Ravi, Afshin Beheshti, Nasséra Abermil, Frederick Lansigan, William Kinlaw, Nirupa R Matthan, Maisarah Mokhtar, Frank C Passero, Patrick Puliti, Kevin A David and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 2 countries.

Dashnamoorthy RaviDivision of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Afshin BeheshtiStanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, United States.
Nasséra AbermilAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Service d'Hématologie Biologique, Paris, France.
Frederick LansiganDepartment of Medicine, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States.
William KinlawDepartment of Medicine, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Nirupa R MatthanJean Mayer United States Department of Agriculture (USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Maisarah MokhtarDivision of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Frank C PasseroDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, United States.
Patrick PulitiDivision of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Kevin A DavidDivision of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Gregory G DolnikowskiJean Mayer United States Department of Agriculture (USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Xiaoyang SuDepartment of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States.
Ying ChenBioinformatics Core, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Mahboubi BijanDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, United States.
Rohan R VarshneyHarold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma, OK, United States.
Baek KimDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, United States.
Sandeep S DaveDepartment of Medicine, Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States.
Michael C RudolphHarold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma, OK, United States.
Andrew M EvensDivision of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Rutgers Cancer Institute of New JerseyDartmouth College · USEmory University · USJohnson University · USUniversity of Oklahoma Health Sciences Center · USDuke Medical Center · USHôpital Saint-Antoine · FRJean Mayer Human Nutrition Research Center on Aging · USMassachusetts Institute of Technology · USRutgers, The State University of New Jersey · USUnited States Department of Agriculture · USUniversity of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and

Indexed as

FASNlipid metabolismmetabolomicsnon-Hodgkin lymphomanucleotidespentose phosphate pathway

Identifiers

PMID34765544
PMCPMC8576537
OpenAlexW3209023420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.