Evidence map›Paper›PMID 34765512›Full record

ArticleJournal of traditional and complementary medicine2021

Inhibitory role of a smart nano-trifattyglyceride of

Arijit Ghosh, Tanaya Roychowdhury, Rajesh Nandi, Rituparna Maiti, Narendra N Ghosh, Sabir A Molla, Soma Mukhopadhyay, Chandraday Prodhan, Keya Chaudhury, Priyabrata Das and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Green Synthesized Zinc Oxide Nanoparticles UsingAntioxidants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Arijit GhoshDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Tanaya RoychowdhuryCancer Biology and Inflammatory Disorder Division, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700032, India.
Rajesh NandiDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Rituparna MaitiDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Narendra N GhoshDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Sabir A MollaDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Soma MukhopadhyayDepartment of Molecular Biology and Gynaecological Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata, 700094, India.
Chandraday ProdhanDepartment of Molecular and Human Genetics, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700032, India.
Keya ChaudhuryDepartment of Molecular and Human Genetics, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700032, India.
Priyabrata DasDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Nirmal K SarkarDepartment of Biological Sciences, Presidency University, 86/1, College Street Road, Kolkata, 700073, India.
Samit ChattopadhyayDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, India.
Rittwika BhattacharyaDepartment of Molecular Biology and Gynaecological Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata, 700094, India.
Chinmoy K BoseDepartment of Molecular Biology and Gynaecological Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 3081 Nayabad, Kolkata, 700094, India.
Dilip K MaitiDepartment of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
University of Calcutta · INIndian Institute of Chemical Biology · INNetaji Subhas Chandra Bose Cancer Research Institute · INBirla Institute of Technology and Science, Pilani · INPresidency University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimEpithelial ovarian cancer has the deadliest prognosis amongst gynaecological cancers, warranting an unmet need for newer drug targets. Based on its anticancer as well as abortifacient potential, EXPERIMENTAL PROCEDURE: Effect of RESULTS AND

conclusionCrude MRE displayed cytotoxic activity, induced apoptosis, and attenuated expression of FSHR and c-Myc in ovarian cancer cell line OAW42. MRE also attenuated expression of CD31, FSHR, and c-Myc in tumour xenograft mouse model. Finally, the active compound purified from ethyl acetate-n-hexane subfraction ofMRE, that attenuated viability of ovarian carcinoma cell lines and reduced FSHR and c-Myc expression, was identified as a naturally hydrated-trifattyglyceride, showing aDFT-optimized folded amphipathic structure for easy transportation through hydrophilic and hydrophobic regions in a biological system, indicating its immense therapeutic relevance in epithelial ovarian carcinoma.

Indexed as

Antitumor activityBioactivity guided structural identificationDensity functional theoryDEPT, Distortionless enhancement by polarization transferDFT, Density-functional theoryDynamic light scatteringESI, Electrospray ionizationFSHR, follicle-stimulating hormone receptorFT-IR, Fourier Transform Infrared SpectroscopyMice xenograft modelMRE, Moringa root extractNMR, Nuclear Magnetic ResonanceNuclear magnetic resonanceScanning electron microscopyUV-VIS-NIR, Ultraviolet–visible–near infrared spectroscopy

Identifiers

PMID34765512
PMCPMC8572721
OpenAlexW3144603330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.